Can Humans Become Physically Immortal? | Brian Kennedy, Ph.D.

Sign up to receive Peter's email newsletter: https://bit.ly/4c602k2 Watch the full episode: https://youtu.be/7yNvz_0Q1eQ Become a member to receive exclusive content: https://bit.ly/3UkxydK This clip is from episode #357 ‒ A new era of longevity science: models of aging, human trials of rapamycin, biological clocks, promising compounds, and lifestyle interventions | Brian Kennedy, Ph.D. In this clip, they discuss: - Hallmarks vs. Pillars of Aging – While frameworks like “hallmarks” and “pillars” of aging provide structure, they don't explain the true cause of aging, as everything is highly interconnected - Interconnected Pathways Over Isolated Targets – Interventions like rapamycin affect multiple hallmarks, highlighting that aging is a network of interdependent processes, not separate targets - Aging Is About Homeostasis – Healthy aging is framed as the body’s ability to maintain balance and respond to damage, rather than targeting individual biological changes - Inflammation as a Central Player – In experiments, inflammation consistently emerges as a strong signal tied to aging and longevity interventions, showing up in aging clocks and biomarker analysis - Causality Between Hallmarks Is Unclear – The discussion debates whether mitochondrial dysfunction causes epigenetic changes or vice versa, reflecting the challenge in defining primary drivers -------- About: The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, and all that goes into that from physical to cognitive to emotional health. With over 90 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, and much more. Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan. Learn more: https://peterattiamd.com Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Podcasts: http://bit.ly/TheDriveGoogle Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures and the companies I invest in or advise, please visit my website where I keep an up-to-date and active list of such companies. For a full list of our registered and unregistered trademarks, trade names, and service marks, please review our Terms of Use: https://peterattiamd.com/terms-of-use/