IGF-1 Signaling: A Key Pathway in Cancer, Longevity & Drug Development

The content of this video is based on Xu Y, Wei J, Wang W, Mao Z, Wang D, Zhang T, Zhang P. Oleanolic Acid Slows Down Aging Through IGF-1 Affecting the PI3K/AKT/mTOR Signaling Pathway. Molecules. 2025 Feb 6;30(3):740. doi: 10.3390/molecules30030740. PMID: 39942843; PMCID: PMC11820160. The IGF-1 signaling pathway plays a crucial role in cell proliferation, longevity, and DNA repair, making it a key target for cancer therapy and anti-aging research. In this video, we break down how IGF-1 activates the PI3K-AKT-mTOR pathway, driving DNA replication and cell growth. We also explore how targeted therapies, such as IGF-1R and mTOR inhibitors, are being developed to suppress tumor growth and enhance longevity. Understanding this pathway opens new doors for precision medicine in cancer, aging-related disorders, and metabolic diseases. Watch now to learn more!