Paul Robbins on Senescence, Senolytics & Extending Healthspan

Dr. Paul Robbins, Professor at the University of Minnesota and Associate Director at the Masonic Institute on the Biology of Aging and Metabolism, explains how clearing senescent cells (with senolytics) can improve healthspan and possibly delay age-related diseases. He covers the latest research, mechanisms behind senescence, how NAD+ ties into it, and why aging itself is the main target. Chapters: 00:00 – Introduction 00:14 – What are Senescent Cells? 01:14 – What Are Senolytics? 02:09 – Why Paul Started Studying Aging 03:25 – The Goal: Healthspan, Not Just Lifespan 04:34 – Hallmarks of Aging and NAD+ 06:02 – Do NAD+ Supplements Work? 07:16 – Can We Measure Senescence in the Body? 08:16 – Senolytics in Clinical Use 09:09 – Diseases Being Targeted First 10:36 – Are Senolytics Safe? 12:03 – Will They Make Us Live to 150? 13:44 – Reducing Comorbidities Through Aging Research 15:02 – How Fast the Field Is Moving 16:16 – Why Most Anti-Aging Products Don’t Work 17:54 – Cultural Views on Aging 19:44 – Making Aging Interventions Fair and Equitable 21:44 – New Hallmarks of Aging 24:17 – How AI Helps Target Senescent Cells 25:54 – Distinguishing Senescent vs Inflammatory Cells 27:12 – Different Types of Senolytics 28:49 – Targeting Specific Cell Types 30:07 – Can We Vaccinate Against Aging? 31:34 – Personalized Approaches and Biomarkers 33:24 – Clinical Trials and What They Measure 34:40 – Lessons from Centenarians 35:01 – Final Thoughts #PaulRobbins #Senolytics #HealthyAging #NADplus #AgingResearch #CellularSenescence #Healthspan #Geroscience #UniversityOfMinnesota #AntiAging