Episode #5 - Professor Alexandra Stolzing: Working hard to get us to longevity escape velocity

🚀 Detailed show notes are available in the LEVITY newsletter: https://peterottsjo.beehiiv.com/ 🚀 Don't forget to SUBSCRIBE to our channel: https://www.youtube.com/channel/UCQ2g_IsL0inKrkc6omolPdA?sub_confirmation=1 🚀 Looking for LEVITY Merch? https://levity-7.creator-spring.com/ Professor Alexandra Stolzing is a pioneer in biogerontological engineering at Loughborough University. With over two decades of experience, and as the former Vice President of Research at SENS Research Foundation, Prof. Stolzing shares insights on: Targeting senescent cells for anti-aging therapies Revolutionizing cryopreservation techniques Developing breath-based aging biomarkers Harnessing AI for rapid drug discovery in aging research Classifying aging as a disease The Longevity Biotech Fellowship Learn how her journey from Germany to the UK shaped her multidisciplinary approach to solving aging. Discover the challenges and opportunities in longevity research, including the critical need for basic science funding. ------------------------------------------------------------ ------------------------------------------------------------ ⏰⏰ CHAPTERS ⏰⏰ 00:00 Introduction 02:10 When Will We Reach Longevity Escape Velocity? 03:11 Background and Interdisciplinary Approach 05:05 Alexandra is a Generalist in Aging Biology 07:04 How Alexandra Decides What to Focus on 09:38 "Enjoyable to be Alive" - Why Alexandra Became a Biogerontologist 14:22 "I Never Thought About Giving Up" 16:48 Sens Research Foundation and the Repair Approach 20:36 Cellular Garbage 25:38 Loss of Stem Cells 26:53 How Important are Mitochondria? 28:33 Hallmarks of Aging 32:44 Bombarding the Public With Promises 36:03 Current Work on Senescent Cells 40:33 The Good and The Bad of Senescent Cells 43:16 When Can We Expect to Have Senolytics on The Market? 45:45 Importance of Biomarkers 47:44 Breath-Based Biomarkers 54:59 The Role AI Can Play 56:33 Large Language Model for Protein Discovery 01:00:32 Challenges in Cryopreservation and Cryoprotectants 01:21:19 Better Model for Brain Aging 01:26:38 Alexandra's Role in The Longevity Biotech Fellowship 01:33:42 The Potential PR Problem With The Replacement Strategy 01:36:14 The Wonderful Longevity Biotech Fellowhip Retreats 01:38:22 Hope and Concerns for the Future of Aging Research 01:45:26 Classifying Aging as a Disease 01:52:35 How to Connect With Alexandra 01:52:57 Alexandra's lifestyle tip