Why Eating Less Slows Aging | Caloric Restriction & Longevity with Dr. Rozalyn Anderson

ReProgram Episode 4 In this episode of the Reprogram Podcast, Dr. George Murphy hosts Dr. Rozalyn Anderson, a leading expert in caloric restriction and metabolism and how they impact healthful aging. They delve into the science of aging, focusing on caloric restriction and its impact on longevity. Dr. Anderson shares her journey from yeast genetics to studying aging in animal models, and finally, to applying what was learned to humans, highlighting the metabolic processes that contribute to aging and how caloric restriction can delay age-related diseases. The discussion also covers the potential of geroprotectors like rapamycin, the possibilities of radical age reversal, and how we should train the next generation of scientists and clinicians. Keywords caloric restriction, aging, metabolism, longevity, geroprotectors, rapamycin, geroscience, regenerative medicine, aging biology, gerontology Takeaways Caloric restriction is the gold standard for studying longevity interventions. Metabolism plays a crucial role in aging processes. Caloric restriction can delay the onset of age-related diseases. Rapamycin shows promise as a geroprotector. Energy efficiency is key to metabolic resilience. Human trials like CALERIE align with animal studies on aging. Methylation clocks offer insights into biological age. Functional outcomes are vital in aging research. Geroprotectors aim to offset age-related conditions. Collaboration between academia and industry is essential. Office Artifact On the desk: The Mongkhon or Muay Thai Headband traditionally worn by Thai martial artist as they enter the ring. Bangkok, Thailand Chapters 00:00:00 Introduction to Dr. Rozalyn Anderson and Caloric Restriction 00:03:04 Understanding Caloric Restriction 00:06:44 We Are What We Eat! 00:08:38 Caloric Restriction as the “Gold Standard’ of Slowing Aging 00:10:03 Rapamycin as a Longevity Intervention 00:11:30 Exploring Geroprotectors 00:14:48 What is Aging and How Do We Measure It? 00:16:40 Defining Geroprotection and Longevity 00:18:55 The Role of the NIH in Aging Research 00:22:12 Collaboration Between Academia and Industry 00:23:38 The Realities of Age Reversal 00:26:33 Personal Reflections on Aging and Lifestyle Notes: The Interventions Testing Program (ITP): https://www.nia.nih.gov/research/dab/interventions-testing-program-itp The National Institute on Aging: https://www.nia.nih.gov/