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Ever wondered why one bad knee often leads to more joint pain as you get older? This video dives into how aging increases inflammation, not just as simple wear and tear, but as a chain reaction within our tissues. We explore the role of senescent cell accumulation, which leads to a phenomenon called Senescence-Associated Secretory Phenotype (SASP), contributing to chronic inflammation. Understanding cellular senescence is crucial for overall health and wellness. Chapters: 00:00 Why Inflammation Spreads With Age (It’s Not Just Wear & Tear) 01:00 Meet the “Zombie Cells”: Senescent Cells Explained 02:02 SASP: How One Bad Cell Poisons the Neighborhood 03:06 Why Your Body Creates Senescent Cells (Cancer Protection Tradeoff) 03:55 The Real Problem: Aging Slows the Immune Cleanup Crew 04:37 The Breakthrough Compound: Odin as a Senolytic (Mayo Clinic Results) 05:04 How Odin Works + Human Trials So Far 05:39 The “Hit-and-Run” Protocol: Dosing, Timing, and Fat-Containing Meals 06:51 Daily Low-Dose vs Monthly Senolytic Cycles 07:03 Key Takeaways, Realistic Expectations, and Wrap-Up 🔬KEY RESEARCH STUDIES: 2018 Mayo Clinic/Scripps Fisetin Study: Yousefzadeh et al., "Fisetin is a senotherapeutic that extends health and lifespan" * Fisetin was most potent of 10 flavonoids tested * Eliminated ~70% of senescent cells in culture * Extended lifespan 10% in aged mice * Reduced age-related pathology across multiple tissues https://pubmed.ncbi.nlm.nih.gov/30279143/ 2024 Review - Fisetin as Senotherapeutic Agent: Tavenier et al., "Fisetin as a senotherapeutic agent: Evidence and perspectives" * Comprehensive review of fisetin mechanisms and human trials * Safety profile and pharmacokinetics https://www.sciencedirect.com/science/article/pii/S0047637424000952 Ongoing Human Trials: * NCT05595499: Frailty in older breast cancer survivors (20mg/kg protocol) * NCT05758246: Sepsis outcomes in elderly patients * NCT06133634: Vascular function in older adults * NCT06431932: Safety/pharmacokinetics in healthy volunteers Senescence-Associated Secretory Phenotype (SASP): Review of SASP mechanisms and role in aging https://www.nature.com/articles/s41413-024-00375-z Fisetin vs Other Senolytics: Comparison of fisetin, quercetin, and dasatinib+quercetin combinations https://www.lifeextension.com/magazine/2021/2/fisetin-senolytic-benefits ⬇️ Discount Codes & Affiliate Links ⬇️ https://www.samedaysupplements.com/ (Discount Code: M2M) https://nutricartel.com/ (15% off code: M2M ) 🔥Don't forget to check out my other reviews! (Search YouTube: David Fredrickson (THEN TYPE WHAT YOUR LOOKING FOR.) 🔥Follow me on Instagram: https://www.instagram.com/ds.fredrickson/ 🔥Checkout our website: https://https://davidfredrickson.com/ 🔥SUBSCRIBE TO THE CHANNEL for fitness content, supplement reviews, bodybuilding information and tips.