Mikhail Blagosklonny on Rapamycin Longevity Series | mTOR drives age-related diseases

The world's leading Rapamycin researcher Mikhail Blagosklonny has a long background in cancer research and one important discovery he made around 2000 was that Rapamycin slowed down senescent cancer cells in different ways. After that step by step his interest in the longevity field increased and he developed the very interesting hyperfunction theory of aging. He has made a huge contribution in moving the Rapamycin longevity field forward and his research papers have impacted many people. For example, the Rapamycin physician Alan Green who thanks to these papers took the decision in 2017 to start prescribing Rapamycin off label. Today Alan Green has the biggest clinical experience in the area with more than 1200 patients. A lot of other physicians have after that also taken these steps and one of those are for example physician Peter Attia. 00:00 Intro 02:32 Current situation and mission 04:07 Why did Rapamycin not prevent his cancer? 06:33 He develops a new type of cancer treatment 08:32 Hyperfunction theory of age-related diseases 10:38 mTOR drives age-related diseases 13:00 Hyperfunction theory and the car analogy 17:20 Difference between new and old version of hyperfunction theory 19:58 Prediction based on hyperfunction theory 21:38 Rapamycin seems to work at any age 23:55 Rapamycin will not make you immortal 26:21 Rapamycin delays lung cancer in mice 27:44 Hyperfunction theory and hormesis 29:13 Rapamycin combination with fasting or calorie restriction 30:33 Rapamycin combination with Acarbose or low carb diet 31:40 Rapamycin combination with exercise 33:04 Exercise and longevity effect 36:10 mTOR sweet spot 38:44 Why do centenarians live a long life? 40:36 Theory of accumulation of molecular damage 44:04 Hyperfunction theory was initially rejected 47:47 Rapamycin research that is missing 51:44 Rapamycin and bacterial infection 53:30 Rapamycin side effect on longevity dose regime 55:50 Rapamycin and pseudo-diabetes 58:51 Rapamycin combination of Acarbose or low carb diet 1:00:09 Rapamycin and increase in lipids 1:02:19 mTOR, mTORC1 and mTORC2 1:05:22 Mikhail's self-experimentation with Rapamycin 1:10:41 Rapamycin and traditional medical care 1:11:13 Rapamycin and unacceptable side effects 1:14:26 Rapamycin and combinations to avoid 1:16:55 Rapamycin and high protein intake 1:18:08 Best time to start taking Rapamycin 1:21:00 Does Rapamycin prevent cancer or not? 1:23:52 Autophagy is a double-edged sword 1:26:51 Important insight from his cancer 1:28:38 Rapamycin rebound effect 1:30:24 Difference between theory and practice 1:32:45 Mikhail's cancer and cancer treatment 1:37:36 Rapamycin and danger Links - Mikhail's research publications https://pubmed.ncbi.nlm.nih.gov/?term=blagosklonny+m - Mikhail's twitter https://twitter.com/Blagosklonny - Homepage https://www.mikhailblagosklonny.com Rapamycin resources - Rapamycin Longevity Lab https://masteronething.com - Rapamycin.news https://www.rapamycin.news - Rapamycin Facebook group https://www.facebook.com/groups/rapamycin - Rapamycin Reddit group https://www.reddit.com/r/Rapamycin Connect with Krister on: Twitter: https://twitter.com/KristerKauppi Instagram: https://www.instagram.com/longevity.lifestyle.hacker Disclaimer: The podcast is for general information and educational purposes only and is not medical advice for you or others. The use of information and materials linked to the podcast is at the users own risk. Always consult your physician with anything you do regarding your health or medical condition.