Morgan Levine, PhD, on PhenoAge and the Epigenetics of Age Acceleration — can we change the pace?

Morgan Levine, Ph.D., developed the phenotypic aging clock called PhenoAge and is a Founding Principal Investigator at Altos Labs, a biotech company that seeks to understand the mechanisms that drive the aging process and age-related diseases with the hope of identifying possible interventions. Additionally, Dr. Levine is an assistant professor of pathology at the Yale University School of Medicine, where her research focuses on the science of biological aging. Dr. Levine completed a postdoctoral fellowship with previous guest Dr. Steve Horvath, a pioneer in the field of epigenetic clocks. EPISODE LINKS: Show notes and transcript: https://www.foundmyfitness.com/episodes/morgan-levine?utm_source=youtube&utm_medium=youtube&utm_campaign=levine_interview "True Age: Cutting-Edge Research to Help Turn Back the Clock" Book: https://www.amazon.com/True-Age-Cutting-Edge-Research-Clock/dp/0593329287 Dr. Morgan Levine on Instagram: https://www.instagram.com/dr.morganlevine/ Dr. Morgan Levine on Twitter: https://www.twitter.com/drmorganlevine PODCAST INFO: Email: https://www.foundmyfitness.com/newsletter?utm_source=youtube&utm_medium=youtube&utm_campaign=levine_interview Apple Podcasts: https://podcasts.apple.com/us/podcast/072-morgan-levine-phd-on-phenoage-and-the-epigenetics/id818198322?i=100055736838 Spotify: https://open.spotify.com/show/5QjpaU0o1Q2MkVZwwG3y7d Full interview playlist: https://www.youtube.com/playlist?list=PLJEEAVzHu9KzgkQbe2Thh35VU-HCiId_s Clips playlist: https://www.youtube.com/playlist?list=PLrGxo-5Uw8gI9-1IStYEvNxVukKxZBlmi CHAPTERS: 00:01:19 - What is aging? 00:03:20 - Why biological aging matters to scientists 00:04:45 - Hallmarks of aging 00:05:24 - What are the drivers of aging? 00:06:58 - What CpG methylation says about aging 00:08:59 - The advantage of epigenetic clocks in research 00:10:12 - New generation epigenetic clocks: GrimAge and PhenoAge 00:11:51 - Clinical biomarkers vs. epigenetic clocks 00:12:50 - Differences in aging between organ systems 00:16:47 - Do some people age faster than others? 00:19:05 - Epigenetic age acceleration 00:20:39 - Is age acceleration a genetic risk inherited from your parents? 00:22:27 - The effects of menopause on aging 00:23:16 - Does the pace of epigenetic aging change throughout life? 00:24:39 - How does obesity and human disease affect epigenetic aging? 00:26:12 - Why genes from development may be key to understanding aging 00:27:13 - Determining epigenetic age in non-human mammals (all of them) 00:27:50 - Is aging an accident of evolution or by design? (See also 00:48:20) 00:30:17 - What happens to the epigenetic age of immortal cells if you grow them forever? 00:31:40 - Effects of cancer treatment on epigenetic age 00:35:43 - Severe COVID-19 and accelerated epigenetic 00:36:40 - Are epigenetic changes in aging a cause or consequence? 00:39:23 - Are the CpG sites used by epigenetic clocks functionally meaningful? 00:42:15 - Reversing epigenetic age with interrupted reprogramming techniques 00:49:27 - Therapeutic plasma exchange in aging and pro-geronic blood factors 00:53:23 - The effects of neutral plasma exchange on the brain 00:56:01 - Lifestyle factors that accelerate epigenetic age 00:57:56 - The aging acceleration effect of smoking 00:59:37 - Omega-3 hypermethylation of inflammatory pathways 01:03:23 - Reliability of consumer epigenetic clock tests 01:06:12 - Construct validity of epigenetic clocks 01:12:06 - Thoughts on most exciting research in aging field 01:13:44 - Dr. Morgan Levine's lifestyle habits 01:15:00 - Intermittent fasting effects on epigenetic age SCIENCE OF HEALTHSPAN EMAIL NEWSLETTER: Receive emailed episode notifications and regular updates on the emerging science of healthspan. https://www.foundmyfitness.com/newsletter?utm_source=youtube&utm_medium=youtube&utm_campaign=levine_interview SUPPORT THE CHANNEL: Many of the magnificent resources associated with the FoundMyFitness channel exist directly as a result of our premium membership. As a premium member, listeners get access to our exclusive podcast The Aliquot, monthly Q&As, a special summary of scientific research every other week called the Science Digest, and more. Sign up to become a premium member and nurture the existence of all of the otherwise free resources provided by FoundMyFitness at https://www.foundmyfitness.com/crowdsponsor?utm_source=youtube&utm_medium=youtube&utm_campaign=levine_interview Thank you for watching! SOCIALS: https://twitter.com/foundmyfitness https://facebook.com/foundmyfitness https://instagram.com/foundmyfitness PODCAST: Apple Podcasts: https://podcasts.apple.com/us/podcast/foundmyfitness/id818198322 Spotify: https://open.spotify.com/show/5QjpaU0o1Q2MkVZwwG3y7d #aging #EpigeneticClocks #TrueAge