The 7 Deadliest Causes of Aging (And How Science Can Stop Them) | Ep. 359

In this episode, I sit down with Dr. Aubrey de Grey, the biogerontologist who pioneered the damage-repair approach to aging, coined the concept of longevity escape velocity, and has spent over 25 years arguing that we don't need to fully understand aging to defeat it. Aubrey explains why the field is moving faster than ever but the money is flowing to the wrong places, with investors chasing low-hanging fruit while the most critical and neglected areas of damage repair remain badly underfunded. He breaks down his seven categories of age-related damage including cell loss, cell accumulation, mitochondrial mutations, intracellular waste, extracellular waste like amyloid, cancer-causing mutations, and loss of extracellular matrix elasticity, and explains why this classification has held up for over two decades while the hallmarks of aging have had to be revised from nine to twelve to fourteen. He walks through the results of his first combination mouse trial which stacked telomerase gene therapy, a senolytic, and heterochronic bone marrow transplant and showed additive lifespan extension but did not beat what calorie restriction alone could achieve. His next study stacks eight interventions including Yamanaka factors for epigenetic reprogramming, MSC-derived exosomes, a next-generation senolytic from a Spanish group that modified navitoclax to eliminate platelet toxicity, anti-IL-11 antibodies, CDC-42 inhibition, and more. The target is robust mouse rejuvenation, defined as doubling the remaining lifespan of middle-aged mice from 12 months to 24. He makes the case that achieving this result is the single domino that will cause the dozen most prominent longevity scientists to start making public timeframe predictions, which will mobilize influencers like Joe Rogan and Mr. Beast, which will mobilize the public, which will force governments to tear up regulatory barriers the same way they did for COVID vaccines. His phrase for this: making aging the new COVID. Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://gladdenlongevity.short.gy/gladden-newsletter-yt If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://gladdenlongevity.short.gy/gladden-vsl-yt To learn more about Dr. Aubrey De Grey: Website: https://www.levf.org/ Timestamps 04:07 The hallmarks of aging, the seven categories of damage, and how they synergize... 08:46 Aging under comprehensive medical control within 12 to 15 years from now... 11:30 The body has millions of inputs but a finite number of responses... 21:17 The seven deadly things... cell loss, cell accumulation, mitochondrial mutations, waste, amyloid, cancer, matrix stiffening... 23:50 The first combination mouse trial... telomerase, senolytics, young bone marrow, rapamycin... 25:23 Robust mouse rejuvenation means doubling remaining lifespan from 12 months to 24... 33:30 AI creates insights out of data... it does not create knowledge out of thin air... 34:15 The goal is to make aging the new COVID... 36:00 Joe Rogan, Mr. Beast, and Kim Kardashian are one sentence away from changing everything... 40:00 The hallmarks keep changing from 9 to 12 to 14... his seven deadly things have never changed... 52:23 Step one for his own longevity... avoid dying of anything stupid... Follow Dr. Gladden at:  Instagram: https://www.instagram.com/gladdenlongevity/?hl=en     LinkedIn: https://www.linkedin.com/company/gladdenlongevity    Disclaimer & Disclosures: https://start.gladdenlongevity.com/disclaimer