Neurobiology of Aging Lecture #3: mTOR, Functional and Structural Alterations, and Biomarkers

Neurobiology of Aging Lecture #3: mTOR, Functional and Structural Alterations, and Biomarkers This episode begins by highlighting recent evidence showing adverse effects on the brain of excessive activation of the mTOR pathway as a consequence of dietary branched chain amino acid consumption. Then I describe evidence that Beyond the age of 40 years brain aging results in progressive decrements in function which are associated with reductions in gray matter and synapse numbers particularly in brain regions that play critical roles in memory, executive functions, and task switching. Recent progress has been made in identifying molecular markers of brain aging in samples of blood or cerebrospinal fluid heralding a better understanding of factors that accelerate or retard brain aging. This episode reviews some of the salient research in these areas. LINKS https://pmc.ncbi.nlm.nih.gov/articles/PMC9988262/pdf/elife-81869.pdf https://pmc.ncbi.nlm.nih.gov/articles/PMC10394982/pdf/gbad044.pdf file:///Users/markmattson/Downloads/s41582-025-01105-7%20(2).pdf