Long-term NMN in male and female mice: lifespan and healthspan effects
In mice, long-term NMN reduced frailty in both sexes; median lifespan rose 8.5% only in females, while males showed more physical activity and metabolic changes plus upregulated inflammatory pathways. [1]
Automatic summary · not editorially reviewed
The key findings
The source at a glance
- Study type / format
- Preclinical mouse study (abstract)
- Population / context
- Male and female mice
- Summary based on
- Study abstract
- Publication status
- Preprint · peer-review status not confirmed
- Original publication
- September 21, 2026
NMN and lifespan in male and female mice
The abstract asks whether the NAD+ precursor nicotinamide mononucleotide (NMN) extends lifespan in mammals, noting this was previously unknown. The researchers gave mice long-term NMN and compared healthspan and lifespan in males and females. In females, but not males, NMN increased median lifespan by 8.5% and upregulated mitochondrial function markers in metabolic tissues. These are mouse results from an abstract; they do not show a lifespan benefit in humans.
Supporting source [1]
Frailty, gut bacterium and sex-specific changes
In both sexes, NMN reduced frailty, and this effect was associated with increased abundance of Anaerotruncus colihominis, a butyrate-producing gut bacterium. In males, but not females, NMN increased physical activity and boosted metabolic health, while also upregulating inflammatory pathways, likely due to sex-specific increased expression of NAD+ consumers including CD38. The abstract describes these as associations and likely explanations, not proven causes.
Supporting source [1]
What the mouse abstract can and cannot show
The authors conclude that the results highlight the potential of NAD+ boosters for treating age-related conditions. This is a proposed potential, not a demonstrated treatment. The abstract reports no sample sizes, follow-up duration, dosing or statistical details, and the full text was not reviewed. Because the work is in mice, the findings cannot be transferred directly to human lifespan or health.
Supporting source [1]
How to interpret this
Abstract only; the full text was not reviewed. Sample sizes, follow-up, dosing and statistics are not reported here. Mouse findings do not establish human lifespan or health benefits.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Kane A, Chellappa K, Schultz M, Carr A, Arnold M, Li J, Amorim J, Zheng M, Gao Y, Rich K, Lichter J, Dixon-McDougall T, O'Donnell C, Ibrahim N, Joshi N, Zambrano R, Thompson E, Ouyang S, Tyshkovskiy A, Diener C, Zhu D, Mitchell S, Griffin P, Tian X, Petty C, Conway R, Walsh K, Shelerud L, Duesing C, Mueller A, Li K, McNamara M, Shima R, Tobias-Wallingford H, Ross J, Coppotellii G, de Cabo R, Gladyshev V, Wu L, Yuji I, Gibbons S, Baur J, Rajman L, Sinclair D. · europepmc.org · September 21, 2026