Cinnarizine and Meclizine did not extend lifespan in C. elegans
In this abstract, putative mTOR inhibitors cinnarizine and meclizine did not increase lifespan in the nematode C. elegans at lower doses; at higher doses both shortened lifespan, described as toxic. [1]
Automatic summary · not editorially reviewed
The key findings
The source at a glance
- Study type / format
- Abstract of a lifespan intervention study in a model organism
- Population / context
- The nematode Caenorhabditis elegans
- Summary based on
- Study abstract
- Original publication
- September 14, 2026
Testing putative mTOR inhibitors in C. elegans
The abstract notes that mTOR is a protein kinase and master cell regulator and one of the most validated longevity drug targets; inhibiting mTOR with compounds such as rapamycin has significantly extended lifespan in numerous model organisms. The authors asked whether the novel putative mTOR-inhibiting compounds cinnarizine and meclizine could likewise increase lifespan in the nematode C. elegans.
Supporting source [1]
No lifespan gain at lower doses, shortening at higher
According to the abstract, the tests followed standardized protocols from the Caenorhabditis Intervention Testing Program. The results indicate that cinnarizine and meclizine had no effect on C. elegans lifespan at lower doses, and that both compounds exerted a toxic effect at higher doses, significantly shortening lifespan.
Supporting source [1]
Abstract-only scope of this nematode study
This explainer is based only on the abstract; the full text was not reviewed. The abstract reports lifespan effects in the nematode C. elegans, not human outcomes, and gives no details on doses, sample sizes or replication. The compounds are called putative mTOR inhibitors, so their action on mTOR is not established here. These are associations between compound exposure and lifespan in a model organism, not evidence of benefit for people.
Supporting source [1]
How to interpret this
Abstract only; the full text was not reviewed. Doses, sample sizes, replication and the compounds' actual mTOR action are not reported in the abstract. Findings concern the nematode C. elegans, not humans.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Johnson E, Sedore CA, Coleman-Hulbert AL, Onken BD, Achanta VM, Song Y, Cortopassi G, Lithgow GJ, Driscoll M, Phillips PC. · europepmc.org · September 14, 2026