Probiotic strains and L-aspartic acid extend lifespan in C. elegans
In the nematode Caenorhabditis elegans, three probiotic strains and later L-aspartic acid supplementation were reported to prolong lifespan, with got-1.2 and adk-1 described as regulators of L-aspartic acid effects. [1]
Automatic summary · not editorially reviewed
The key findings
The source at a glance
- Study type / format
- Preclinical study in a nematode model (abstract)
- Population / context
- Caenorhabditis elegans nematodes
- Summary based on
- Study abstract
- Publication status
- Preprint · peer-review status not confirmed
- Original publication
- September 8, 2026
Probiotic strains tested in C. elegans
The abstract reports that three probiotic strains — Lactiplantibacillus plantarum Q7, Bifidobacterium animalis subsp. lactis F1-7 and Lacticaseibacillus paracasei J5 — prolonged the lifespan of Caenorhabditis elegans. This was linked to changes in metabolic homeostasis: higher NAD/NADH ratios, reduced lipid accumulation and increased ATP production. The work is described as a study in this nematode, not in humans.
Supporting source [1]
L-aspartic acid and lifespan in the worm
Using untargeted metabolomics, the authors identified L-aspartic acid (L-ASP) as a key mediator linking pathways of energy and amino acid metabolism. Adding L-ASP externally reportedly mimicked the probiotics' effects and extended mean lifespan by up to 11.91% at the optimal concentration of 5 mM. Genetic analyses described got-1.2 as the essential upstream regulator of the worm's own L-ASP production and adk-1 as the indispensable downstream effector in purine metabolism.
Supporting source [1]
Scope: worm model, abstract only
The authors describe a causal link between probiotic intervention and anti-aging phenotypes in C. elegans and propose L-ASP as a potential biomarker for screening geroprotective probiotics. These are findings in a nematode model; they do not show that the strains or L-ASP extend human lifespan or improve human health. The abstract does not report sample sizes, replicate numbers or the full experimental design.
Supporting source [1]
How to interpret this
Abstract only; the full text was not reviewed. All results concern the nematode Caenorhabditis elegans, not humans. Sample sizes, replicate numbers and full methods are not reported in the abstract.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Cao J, Liu Y, Jiang L, Gong P, Li Z, Yi H. · europepmc.org · September 8, 2026