Adaptive laboratory evolution of yeast under high glucose: longevity-adapted lineages
In an abstract, laboratory yeast BY4742 evolved under 300 g/L glucose with mutagenesis showed greater cumulative survival in a chronological lifespan assay; lineages shared a ribosome-associated core and converged on tryptophan-kynurenine metabolism despite divergent transcriptomes. [1]
Automatic summary · not editorially reviewed
The key findings
Adaptive laboratory evolution under 300 g/L glucose combined with ethyl methanesulfonate mutagenesis generated multiple independent longevity-adapted lineages of the laboratory haploid strain BY4742. [1]
Evolved strains showed significantly greater cumulative survival in the chronological lifespan assay, improved survival under high-glucose stress and shortened lag phases without major growth-rate reductions. [1]
Despite divergent transcriptomes, metabolomic remodeling converged, with tryptophan metabolism the most consistent shared signature alongside changes in kynurenine, xanthurenic acid, nicotinamide and indole-3-acetic acid. [1]
The source at a glance
- Study type / format
- Abstract of an adaptive laboratory evolution study with mutagenesis, transcriptomics and metabolomics
- Population / context
- Laboratory haploid Saccharomyces cerevisiae strain BY4742 under 300 g/L glucose
- Summary based on
- Study abstract
- Publication status
- Preprint · peer-review status not confirmed
- Original publication
- August 27, 2026
Yeast BY4742 evolved under 300 g/L glucose
The abstract describes adaptive laboratory evolution of the laboratory haploid strain BY4742 under 300 g/L glucose, combined with ethyl methanesulfonate mutagenesis, to generate multiple independent longevity-adapted lineages. The stated context is that excessive glucose accelerates cellular aging and impairs fermentation robustness in industrial Saccharomyces cerevisiae, while adaptation to persistent glucose excess with long-term viability is not fully understood.
Supporting source [1]
Greater cumulative survival and shorter lag phases
According to the abstract, the evolved strains showed significantly greater cumulative survival across the chronological lifespan assay, together with improved survival under high-glucose stress and shortened lag phases without major reductions in growth rate. Transcriptomic analysis revealed a conserved ribosome-associated adaptive core shared among lineages. Beyond this, W2 strains mainly remodeled translational allocation and biosynthetic pathways, E strains emphasized proteostasis, autophagy, membrane remodeling and mitochondrial functions, and W3 strains showed extensive restructuring of central carbon metabolism, protein folding and quality control.
Supporting source [1]
Convergent tryptophan-kynurenine metabolome across lineages
Despite the transcriptomic divergence, the abstract reports clear convergence in metabolomic remodeling. Tryptophan metabolism was the most consistent shared signature, accompanied by coordinated alterations in kynurenine, xanthurenic acid, nicotinamide and indole-3-acetic acid. The authors describe these findings as consistent with a hierarchical model in which distinct transcriptional trajectories converge on remodeling of tryptophan-kynurenine metabolism and NAD-associated nucleotide and redox networks, offering a systems-level framework for understanding adaptive aging and a basis for engineering robust industrial yeast strains.
Supporting source [1]
How to interpret this
This is an abstract; the full text was not reviewed. Findings concern laboratory haploid yeast BY4742 under high glucose, not humans or human lifespan. The abstract reports no sample sizes, lineage counts, follow-up durations or statistical details, and the proposed hierarchical model and engineering basis are frameworks, not validated products.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Liu Y, Huang J, Wang L, Wu Z. · europepmc.org · August 27, 2026