Systems view of aging and stress resilience in centenarians
This abstract describes aging as a dynamic, time-dependent process of functional decline shaped by interconnected hallmarks, and presents centenarians as a model of successful aging supported by genetic, epigenetic, metabolic and immunological adaptations. [1]
Automatic summary · not editorially reviewed
The key findings
The abstract describes aging as a dynamic, time-dependent process of progressive functional decline across biological systems, with interconnected hallmarks. [1]
Centenarians are presented as a model of successful aging whose exceptional longevity is supported by coordinated genetic, epigenetic, metabolic and immunological adaptations. [1]
The authors summarize biological drivers and frameworks of aging and examine major animal models, without reporting new measurements. [1]
The source at a glance
- Study type / format
- Review abstract
- Population / context
- Aging biology generally, with centenarians as a model and major animal models discussed
- Summary based on
- Study abstract
- Original publication
- August 11, 2026
Aging as interconnected hallmarks
The abstract defines aging as a dynamic and time-dependent process with progressive functional decline across biological systems. It names genomic instability, telomere attrition, loss of proteostasis, mitochondrial dysfunction and immunosenescence as widely described hallmarks. These reflect distinct yet interconnected mechanisms. Rather than acting alone, the processes arise from interactions among cellular stressors, impaired repair and cumulative maladaptive responses. This system-level view is offered to explain inter-individual variability in aging trajectories.
Supporting source [1]
Centenarians as a model of successful aging
Centenarians are described as an extreme and informative model of successful aging, in which the balance between damage accumulation and repair shifts toward maintaining physiological function. Their exceptional longevity is said to be supported by coordinated genetic, epigenetic, metabolic and immunological adaptations that enhance resilience to age-related stressors. The abstract states that aging outcomes reflect a dynamic equilibrium between damage and repair, and that understanding how this balance is modulated in long-lived individuals may inform strategies for healthy aging and delaying age-related diseases.
Supporting source [1]
Animal models and review scope
The authors say they summarize biological drivers and theoretical frameworks of aging in an integrative context, focusing on mechanisms linked to extended healthspan in centenarians. They also examine the contribution of major animal models, highlighting their complementary roles in clarifying conserved and species-specific aging pathways. The abstract does not report new measurements, sample sizes or follow-up. It is a summary of a review, so the described mechanisms and animal findings are presented as background, not as demonstrated human lifespan benefits.
Supporting source [1]
How to interpret this
This is an abstract only; the full text was not reviewed. No sample sizes, follow-up, new measurements or effect estimates are reported. Animal-model findings and proposed mechanisms are background, not demonstrated human lifespan benefits.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Sideri S, Cosentino M, Forcina L, Musarò A. · europepmc.org · August 11, 2026