Review: Nutrition and Measured Biological Age in Animals and Humans
This review reports that calorie restriction, Mediterranean diet, intermittent fasting and micronutrient supplementation are associated with lower measured biological age, while obesity, inflammatory dietary patterns and malnutrition are associated with accelerated aging in certain populations and measurement platforms. [1]
Automatic summary · not editorially reviewed
The key findings
The review examines nutritional strategies affecting biological age in model organisms and humans, including recent clinical trials using composite omics-based aging biomarkers. [1]
Calorie restriction, Mediterranean diet, intermittent fasting and micronutrient supplementation are associated with reduced biological age, while obesity, inflammatory dietary patterns and malnutrition are associated with accelerated aging in certain populations and on certain measurement platforms. [1]
Proteomic analyses suggest organ systems may age at heterogeneous rates, with dietary patterns differentially affecting organ-specific aging trajectories. [1]
The source at a glance
- Study type / format
- Review (abstract only)
- Population / context
- Model organisms and humans in reviewed nutritional studies
- Summary based on
- Study abstract
- Original publication
- August 1, 2026
Review scope: diet and biological age in animals and humans
The review examines nutritional strategies that may affect biological age, a measurable indicator of physiological health based on molecular biomarkers. It covers model organisms and humans and highlights recent clinical trials that use composite aging biomarkers built from omics data. The authors describe the evidence as accumulating rather than settled.
Supporting source [1]
Diet patterns linked to lower or accelerated biological age
Calorie restriction, Mediterranean diet, intermittent fasting and micronutrient supplementation are associated with reduced biological age. Obesity, inflammatory dietary patterns and malnutrition are associated with accelerated aging. These links are described as associations in certain populations and on certain measurement platforms, not as proven causes.
Supporting source [1]
Organ-specific aging and translation challenges
Proteomic analyses indicate that organ systems may age at different rates, and dietary patterns may affect organ-specific aging trajectories differently. The review notes difficulties in extrapolating from animal models and heterogeneity in how individuals respond to interventions. It presents precision nutrition as a promise, not an established approach.
Supporting source [1]
How to interpret this
This is an abstract of a review; the full text was not reviewed. The abstract reports associations, not causes, and does not give trial sizes, follow-up durations or effect sizes. It notes difficulties extrapolating from animal models and heterogeneous intervention responses.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Albright SM, Poganik JR, Gladyshev VN. · europepmc.org · August 1, 2026