Amino acids and arterial stiffness progression in Japanese older adults
In a prospective cohort of 592 Japanese adults aged 65 and older, baseline glutamic acid, isoleucine and leucine were associated with greater later increase in arterial stiffness measured by CAVI. [1]
Automatic summary · not editorially reviewed
The key findings
The analysis included 592 Japanese adults aged 65 or older with repeated CAVI measurements over a mean follow-up of 3.2 years. [1]
Glutamic acid, isoleucine and leucine at baseline were significantly associated with a greater later increase in CAVI. [1]
The conclusion describes these amino acids and branched-chain amino acid-derived indices as independent predictors of arterial stiffness progression assessed by CAVI. [1]
The source at a glance
- Study type / format
- Prospective cohort analysis (abstract).
- Population / context
- Community-dwelling Japanese adults aged 65 or older in the Kyotango Longevity Cohort Study.
- Summary based on
- Study abstract
- Original publication
- July 30, 2026
Kyotango cohort: baseline amino acids, repeated CAVI
This prospective analysis of the Kyotango Longevity Cohort Study followed 592 community-dwelling Japanese adults aged 65 or older. Fasting blood samples at baseline were analyzed for 23 amino acids with sufficient data. Arterial stiffness was assessed with the cardio-ankle vascular index (CAVI), a measure of arterial stiffness, and CAVI was measured repeatedly over a mean follow-up of 3.2 years (plus or minus 0.5 years). The question was whether baseline amino acid profiles predict later progression of arterial stiffness in this population.
Supporting source [1]
Three amino acids linked to greater CAVI increase
Initial screening analyses adjusted for age, sex and baseline CAVI identified glutamic acid, isoleucine and leucine as significantly associated with a greater increase in CAVI. The conclusion names these three amino acids, together with indices derived from branched-chain amino acids, as independent predictors of longitudinal progression of arterial stiffness as assessed by CAVI. These are associations from an observational cohort, not evidence that the amino acids cause stiffness or that changing them alters outcomes.
Supporting source [1]
Abstract-only scope of the Kyotango analysis
The available text is an abstract; the full text was not reviewed. The abstract reports the cohort size, follow-up and the three amino acids, but does not give effect sizes, confidence intervals or the full set of adjustment models. It also does not describe how CAVI progression was defined beyond repeated measurement. The findings therefore remain limited to what the abstract states about this older Japanese cohort.
Supporting source [1]
How to interpret this
Abstract only; the full text was not reviewed. Effect sizes, confidence intervals and full adjustment models are not reported in the abstract, and CAVI progression is not further defined there. Associations do not establish causation.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Oishi M, Kitani T, Tamagaki S, Ouchi N, Adachi A, Matoba Y, Ikeda K, Naito Y, Kamitani T, Matoba S. · europepmc.org · July 30, 2026