Insulin resistance rises and mild cognitive impairment in adults followed from 57 to 69
In adults followed from 57 to 69 years, greater increases in insulin resistance and fasting insulin were associated with higher risk of mild cognitive impairment; the MCI group also showed a greater decline in health-related quality of life. [1]
Automatic summary · not editorially reviewed
The key findings
The source at a glance
- Study type / format
- Observational follow-up study (abstract)
- Population / context
- Adults followed from 57 to 69 years of age, grouped as MCI or non-MCI at follow-up.
- Summary based on
- Study abstract
- Original publication
- June 23, 2026
Follow-up from 57 to 69 and MCI grouping
The abstract describes a follow-up study. Participants were followed from 57 to 69 years of age and divided into an MCI group and a non-MCI group according to their CERAD total score at follow-up. Changes in HOMA-IR and fasting insulin during follow-up were determined. Smoking, alcohol consumption, physical activity, depressive symptoms and health-related quality of life came from questionnaires; body weight, height, blood pressure and LDL cholesterol were measured at baseline and follow-up. Adjustments were made for baseline cognitive performance, professional education and physical activity.
Supporting source [1]
Higher MCI risk with rising insulin measures
Greater increases in HOMA-IR (odds ratio 2.20, 95% confidence interval 1.05–4.62) and fasting insulin (odds ratio 3.49, 95% confidence interval 1.48–8.23) were associated with increased risk of MCI. Lower cognitive performance at baseline (odds ratio 6.33; 95% confidence interval 3.27–12.29), lower education (odds ratio 3.94, 95% confidence interval 1.76–8.81) and lower physical activity (odds ratio 2.44, 95% confidence interval 1.06–5.65) were also associated with higher MCI risk at follow-up. These are associations, not proof that insulin resistance causes MCI.
Supporting source [1]
Quality-of-life decline in the MCI group
The abstract reports a greater decline in health-related quality of life among the MCI group. Its conclusion states that insulin resistance is a risk factor for MCI and that MCI causes worsening of health-related quality of life during aging. The causal wording of that conclusion goes beyond what an observational follow-up can establish. The abstract does not report how many people took part, how many developed MCI, or how long follow-up lasted beyond the stated age range.
Supporting source [1]
How to interpret this
Abstract only; the full text was not reviewed. The abstract does not report sample size, number of MCI cases, follow-up duration beyond the age range, or effect estimates for the quality-of-life comparison. Its causal conclusion exceeds what an observational follow-up supports.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Rotonen S, Auvinen J, Bloigu A, Härkönen P, Jokelainen J, Timonen M, Keinänen-Kiukaanniemi S. · europepmc.org · June 23, 2026