Review: NAD+ metabolism as a link between nutrition and aging
This review integrates evidence on how NAD+ metabolism and signaling influence cellular and organismal aging, with emphasis on nutritional factors that modulate these processes. It proposes NAD+ as a unifying framework linking nutrition, metabolic resilience and healthy aging. [1]
Automatic summary · not editorially reviewed
The key findings
The review states that aging is the greatest risk factor for many prevalent diseases, including diabetes, cancer, cardiovascular disease and neurodegenerative disorders. [1]
Emerging studies are said to implicate diminished NAD+ levels as a contributor to several hallmarks of aging. [1]
The review proposes NAD+ as a unifying framework linking nutrition, metabolic resilience and the mechanisms of healthy aging and disease. [1]
The source at a glance
- Study type / format
- Review abstract
- Population / context
- Cells and organisms discussed in aging research, as summarized in the review abstract
- Summary based on
- Study abstract
- Original publication
- June 2, 2026
Aging, disease and disrupted cellular homeostasis
The review states that aging is the greatest risk factor for many prevalent diseases, including diabetes, cancer, cardiovascular disease and neurodegenerative disorders. A common thread is disruption of cellular and metabolic homeostasis, and all hallmarks of aging converge on mechanisms that disrupt how cells communicate, interact and coordinate their functions.
Supporting source [1]
Diminished NAD+ and hallmarks of aging
Emerging studies are said to implicate diminished NAD+ levels as a contributor to several hallmarks of aging, underscoring a regulatory role in age-dependent decline. The review notes it remains unclear whether aging drives metabolic decline, whether metabolic dysregulation accelerates aging, or both. A growing body of evidence suggests NAD+ metabolism may be a key link between disrupted communication and metabolic dysfunction.
Supporting source [1]
Nutritional factors and a proposed unifying framework
The review integrates current insights into how NAD+ metabolism and signaling influence cellular and organismal aging, emphasizing nutritional factors that modulate these processes. Together, these perspectives position NAD+ as a unifying framework linking nutrition, metabolic resilience and the mechanisms of healthy aging and disease. This is a proposed framework, not a validated product or established causal treatment.
Supporting source [1]
How to interpret this
This is an abstract of a review; the full text was not reviewed. The abstract reports no study design, sample, follow-up or outcome data, and it does not establish that changing NAD+ levels causes or prevents aging or disease. The causal direction between aging and metabolic decline is explicitly described as unclear.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
McReynolds MR. · europepmc.org · June 2, 2026