Organ-specific metabolic changes and aging-linked serum markers in progeroid laminopathy
In a cross-species metabolic atlas of progeroid laminopathy, the skin showed the most pronounced changes; serum markers such as increased LPC(18:1e) and LysoPA and decreased D-glucose 1-phosphate and NAD showed concordant trends in physiologically aged healthy people. [1]
Automatic summary · not editorially reviewed
The key findings
The atlas combined lipidomic and metabolomic profiling of heart, lung, skin and serum from HGPS mouse models and human PL cohorts. [1]
Organ-specific metabolic alterations were found, with the most pronounced changes in the skin at the omics level. [1]
Serum markers showed concordant trends in independent cohorts of physiologically aged healthy individuals, indicating partial convergence with normal aging. [1]
The source at a glance
- Study type / format
- Cross-species multi-organ lipidomic and metabolomic profiling study (abstract)
- Population / context
- HGPS mouse models and human progeroid laminopathy cohorts, plus independent cohorts of physiologically aged healthy individuals for serum comparisons.
- Summary based on
- Study abstract
- Original publication
- June 1, 2026
Multi-organ atlas in HGPS mice and human cohorts
The authors built a cross-species, multi-organ metabolic atlas of progeroid laminopathy (PL). They combined lipidomic and metabolomic profiling of heart, lung, skin and serum from Hutchinson-Gilford progeria syndrome (HGPS) mouse models and human PL cohorts. The stated aim was to better understand the molecular mechanisms linking premature and physiological aging, which the authors describe as incompletely understood.
Supporting source [1]
Skin changes and a taurine-TCA-TUDCA axis
The profiling identified organ-specific metabolic alterations. At the omics level, the most pronounced changes were observed in the skin. The authors also report disruption of a taurine-TCA-TUDCA cytoprotective axis, which they interpret as suggesting a coordinated metabolic vulnerability in PL. These are metabolic profiling findings; the abstract does not report clinical outcomes or whether altering this axis changes disease course.
Supporting source [1]
Serum biomarkers and overlap with normal aging
Serum profiling revealed candidate circulating biomarkers: increased LPC(18:1e) and LysoPA, and decreased D-glucose 1-phosphate and NAD. These alterations were conserved across species and showed concordant trends in independent cohorts of physiologically aged healthy individuals. The authors read this as partial convergence between PL-associated and normal aging-related metabolic changes. They describe the biomarkers as clinically accessible but state that future longitudinal validation is needed; the abstract reports no such validation.
Supporting source [1]
How to interpret this
Abstract only; the full text was not reviewed. The abstract reports no sample sizes, follow-up or clinical outcomes, and the biomarker findings are described as candidates warranting future longitudinal validation. The overlap with physiological aging is an association, not evidence of causation.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Hu L, Zhao X, Zhang Y, Wang J, Wang G, Liu X, Feng Z, Yin J, Peng Z, Gao L, Mao J, Shen N. · europepmc.org · June 1, 2026