Narrative review of lifestyle, fasting and drugs proposed for longevity
This narrative review describes lifestyle measures, follow-up of medical guidelines, possible intermittent fasting and medications such as metformin, rapamycin, lithium and certain vitamins as factors discussed for a longer, healthier life; it reports no new study results. [1]
Automatic summary · not editorially reviewed
The key findings
The authors describe longevity as living a longer and healthier life and say many aging studies found it multifactorial, including telomere attrition, mitochondrial dysfunction and loss of intercellular communication. [1]
The review lists good physical activity, appropriate nutrition, healthy sleep patterns and managing life stressors, and mentions a suggestion that intermittent fasting in humans may reduce the risk of some age-related diseases and improve longevity. [1]
The report discusses medications linked to longevity such as metformin, rapamycin, lithium and certain vitamins, and states that clear longevity guidelines are absent. [1]
The source at a glance
- Study type / format
- Narrative review (abstract)
- Population / context
- People addressed by a narrative review on longevity and preventive care
- Summary based on
- Study abstract
- Original publication
- June 1, 2026
Review scope: lifestyle, guidelines and longevity factors
The authors describe longevity as living a longer and healthier life and say it contributes to a community's vitality. They present a narrative review of accepted guidelines for preventive medical management and general healthy-lifestyle measures. They state that many aging studies found longevity to be multifactorial, including telomere attrition, mitochondrial dysfunction and loss of intercellular communication. The first steps they name are lifestyle modification plus appropriate medical care and follow-up aimed at lifelong normal blood pressure, low low-density lipoprotein, avoiding smoking, managing diabetes and following accepted medical guidelines.
Supporting source [1]
Activity, nutrition, sleep, stress and possible fasting
The review lists maintaining good physical activity, appropriate nutrition, healthy sleep patterns and managing various life stressors as part of this approach. It also notes a suggestion that intermittent fasting in humans may reduce the risk of some age-related diseases and improve longevity. This is presented as a suggestion, not as an established effect.
Supporting source [1]
Medications discussed and the review's stated limits
The report discusses medications linked to longevity, such as metformin, rapamycin, lithium and certain vitamins. The authors state that clear guidelines for longevity are absent and that primary care is currently short-staffed; they hope the report helps primary care providers focus on this challenge. Because this is a narrative review, it does not report its own participants, comparison groups or measured outcomes, and the abstract gives no effect sizes or safety data for the named medications.
Supporting source [1]
How to interpret this
Abstract only; the full text was not reviewed. This is a narrative review without reported participants, comparison groups, follow-up or measured outcomes, and the abstract gives no effect sizes or safety data for the named medications.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Rezkalla SH, Kloner RA. · europepmc.org · June 1, 2026