Multiomic plasma signature in diet-restricted Diversity Outbred mice followed to death
In 960 Diversity Outbred mice on intermittent fasting or caloric restriction, plasma metabolites, lipids and proteins changed with caloric intake and were linked to lifespan; the abstract reports associations, not proven causes. [1]
Automatic summary · not editorially reviewed
The key findings
The study analyzed 2,234 plasma samples from 960 Diversity Outbred mice given intermittent fasting or caloric restriction and followed to natural death. [1]
Aging showed a biphasic signature with sharp acceleration beyond 85% of lifespan, and SODE and VCAM1 were top lifespan predictors in modeling. [1]
Of 9,599 QTL, nine coincided with previously identified lifespan QTLs and were largely related to immune regulation. [1]
The source at a glance
- Study type / format
- Longitudinal multiomic analysis in mice (abstract)
- Population / context
- 960 Diversity Outbred mice given intermittent fasting or caloric restriction
- Summary based on
- Study abstract
- Publication status
- Preprint · peer-review status not confirmed
- Original publication
- May 13, 2026
Plasma samples from 960 mice on two diets
The abstract describes a longitudinal multiomic analysis of 2,234 plasma samples from 960 Diversity Outbred mice. The mice received intermittent fasting or caloric restriction and were followed to natural death. Mass spectrometry quantified 1,512 metabolites, lipids and proteins, and their associations with diet, age and longevity were mapped.
Supporting source [1]
Diet-linked molecular shifts and a late aging phase
According to the abstract, molecular changes induced by dietary restriction scaled with caloric intake and modulated inflammatory, lipid catabolism and oxidative stress pathways. Aging showed a biphasic signature, with sharp acceleration beyond 85% of lifespan, which the authors describe as demarcating terminal decline. Mediation and survival modeling identified superoxide dismutase (SODE) and vascular cell adhesion molecule (VCAM1) as top lifespan predictors.
Supporting source [1]
Genetic loci overlap with known lifespan loci
The genetic analysis revealed 9,599 quantitative trait loci (QTL), regions of the genome linked to measured traits. Nine of these coincided with previously identified lifespan QTLs, and the loci were largely related to immune regulation. The authors present these findings as a multiomic and genetic resource for the aging research community.
Supporting source [1]
How to interpret this
This is an abstract; the full text was not reviewed. It reports associations in mice, not proven causal mechanisms or human lifespan benefits. Design details, effect sizes and uncertainty measures are not given in the abstract.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Fleischman JY, Sandoval C, Vu N, Mullis M, Seitzer P, Chan LJ, Olsson N, Nguyen T, Gaun A, Luciano A, O’Brien J, Vu J, Robinson L, Di Francesco A, Li W, Hackett SR, Keyser R, McAllister FE, Churchill GA, Bennett BD. · europepmc.org · May 13, 2026