IgG glycan profiles and biological aging in 20,405 people across 42 studies
In an abstract, IgG glycome profiles reflecting accelerated biological aging were linked to higher all-cause mortality risk, independent of established clinical risk factors and potential confounders; the full text was not reviewed. [1]
Automatic summary · not editorially reviewed
The key findings
IgG glycome composition was analyzed in 20,405 individuals from 42 studies processed between 2008 and 2025. [1]
Accelerated glycan aging was strongly associated with increased all-cause mortality risk, independent of established clinical risk factors and potential confounders. [1]
Hormone replacement therapy, therapeutic plasma exchange and caloric restriction were associated with reversal of glycan aging. [1]
The source at a glance
- Study type / format
- Abstract of an analysis of IgG glycome composition across 42 studies
- Population / context
- 20,405 individuals from 42 different studies processed at the Genos Glycoscience Research Laboratory between 2008 and 2025.
- Summary based on
- Study abstract
- Publication status
- Preprint · peer-review status not confirmed
- Original publication
- April 23, 2026
IgG glycome measured in 20,405 people
The abstract describes an analysis of IgG glycome composition in 20,405 individuals from 42 different studies, processed at the Genos Glycoscience Research Laboratory between 2008 and 2025. IgG glycosylation is described as a structural modification that modulates IgG effector functions and helps balance inflammation. The abstract states that altered IgG glycosylation has been reported in many diseases, often years before clinical manifestation.
Supporting source [1]
Accelerated glycan aging and mortality risk
Across nearly all diseases, specific IgG glycome profiles reflected accelerated biological aging, according to the abstract. Accelerated glycan aging was strongly associated with increased risk of all-cause mortality, independent of established clinical risk factors and potential confounders. The abstract frames IgG glycans as a possible functional link between chronic inflammation, aging, disease susceptibility and all-cause mortality.
Supporting source [1]
Interventions linked to reversal of glycan aging
The abstract reports that interventions known to reduce mortality risk, including hormone replacement therapy, therapeutic plasma exchange and caloric restriction, were associated with reversal of glycan aging. These are described as associations, not proven causes. The abstract also suggests a possible causal role and biomarker potential for altered IgG glycosylation, but this remains a proposal rather than a demonstrated mechanism.
Supporting source [1]
How to interpret this
This is based on the abstract only; the full text was not reviewed. The abstract does not report study designs, follow-up, effect sizes or how confounders were handled. Associations are not causes, and the proposed causal and biomarker roles remain unproven.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Lauc G, Mijakovac A, Butz E, Vuckovic F, Frkatović-Hodžić A, Kifer D, Deris H, Radovani B, Lukšić F, Cindric A, Gudelj I, Briški NŠ, Josipović G, Yuksel ZS, Ćatić J, Šaler F, Szavits-Nossan J, Hedin C, Šimunović J, Borošak I, Kristic J, Monteiro-Martins S, Pribić T, Hanić M, Pučić-Baković M, Trbojević-Akmačić I, Štambuk T, Štambuk J, Kavur MM, Fančović M, cvetko A, Pezer M, Polašek O, Gornik O, Kiprov D, Verdin E, Younggren B, Newson L, Menni C, Steves C, Spector T, Halfvarsson J, Pochec E, Zabczynska M, Turkalj M, Wilson J, Alarcon-Riquelme M, Aden K, Rosenstiel P, Franke A, Frey N, Schreiber S, Blaak E, Köttgen A, Zoldoš V, Primorac D, Marjanović D, Schultheiss U, Wang W, Rapčan B. · europepmc.org · April 23, 2026