Mouse liver and gallbladder gene activity during aging and fasting
In mice, liver and gallbladder gene activity changed differently with age, and fasting triggered shared fat breakdown but age-specific regulatory programs. [1]
Automatic summary · not editorially reviewed
The key findings
Mouse liver and gallbladder tissue was sequenced at P27, 2 months and 21 months, fed and fasted. [1]
The liver shifted gradually with age from proliferative to immune-dominant states; the gallbladder showed biphasic remodeling. [1]
Fasting induced conserved lipid catabolism in both organs, with age-specific regulatory modules. [1]
The source at a glance
- Study type / format
- Abstract of a mouse bulk RNA sequencing study
- Population / context
- Mouse liver and gallbladder tissue at three developmental stages
- Summary based on
- Study abstract
- Original publication
- April 15, 2026
Mouse liver and gallbladder at three ages
The abstract describes bulk RNA sequencing of mouse liver and gallbladder tissue at three developmental stages: P27, 2 months and 21 months. Tissues were examined under fed and fasted conditions. The authors used clustering methods to map time-related gene expression patterns and age-associated co-expression modules. The stated aim was to see how aging and nutrient stress interact in these two hepatobiliary organs, which the authors say have different roles in metabolism and immune regulation.
Supporting source [1]
Different age patterns in liver and gallbladder
The liver showed a gradual shift with age from proliferative to immune-dominant transcriptional states. The gallbladder showed biphasic remodeling: early immune activation with metabolic suppression, then reactivation of lipid metabolism in old age. Fasting induced conserved lipid catabolism in both organs, while age-specific regulatory modules pointed to distinct adaptive mechanisms. In aged liver, histone remodeling and translational programs were activated while lipid metabolism was suppressed; the aging gallbladder showed reduced insulin responsiveness and autophagic capacity alongside enhanced extracellular matrix reorganization.
Supporting source [1]
Abstract-only mouse findings, not human outcomes
These are transcriptional associations in mice, not evidence of cause or of effects on human lifespan or disease. The abstract reports no sample sizes per group, no effect sizes and no statistical details beyond the clustering methods. It also does not report whether findings were confirmed in other experiments. The full text was not reviewed, so the described organ- and age-specific strategies remain abstract-level observations.
Supporting source [1]
How to interpret this
Abstract only; the full text was not reviewed. Findings are transcriptional associations in mice, with no sample sizes, effect sizes or confirmation reported in the abstract.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Lu Y, Ying P, Song J, Ding W, Feng P, Du J, Ruan C, Liu H. · europepmc.org · April 15, 2026