TyG index and peripheral arterial stiffness in a Chinese community cohort: BMI interaction
In 4729 healthy Chinese adults, a higher triglyceride–glucose (TyG) index was associated with peripheral arterial stiffness but not with carotid-femoral stiffness; the association varied with body mass index. [1]
Automatic summary · not editorially reviewed
The key findings
The study included 4729 healthy Chinese adults from a community-based health survey and measured arterial stiffness at three pulse wave velocity sites. [1]
After adjustment, the TyG index was associated with peripheral arterial stiffness (cdPWV or crPWV) but not with cfPWV. [1]
A significant interaction between the TyG index and BMI was reported for crPWV and cdPWV, with rising risk across TyG quartiles at different BMI levels. [1]
The source at a glance
- Study type / format
- Observational community-based cohort study (abstract).
- Population / context
- 4729 healthy Chinese adults from a community-based health survey.
- Summary based on
- Study abstract
- Publication status
- Preprint · peer-review status not confirmed
- Original publication
- April 9, 2026
TyG index and arterial stiffness in 4729 Chinese adults
The abstract describes a community-based health survey of 4729 healthy Chinese adults. The TyG index was calculated from fasting triglycerides and fasting glucose. Arterial stiffness was measured as pulse wave velocity at three sites: carotid-femoral (cfPWV), carotid-radial (crPWV) and carotid-dorsalis pedis (cdPWV). This is an observational association study, so it cannot show that the TyG index causes stiffness.
Supporting source [1]
Peripheral stiffness linked, cfPWV not; BMI interaction
After adjustment for conventional risk factors, the TyG index was significantly associated with peripheral arterial stiffness, defined as cdPWV above 10.57 cm/s or crPWV above 11.12 cm/s, but not with cfPWV. A significant interaction between the TyG index and body mass index was reported for both crPWV and cdPWV. The risk of elevated crPWV and cdPWV rose across TyG index quartiles at different BMI levels. The conclusion states the TyG index independently predicts peripheral arterial stiffness, particularly in normal-weight adults.
Supporting source [1]
Abstract-only scope of the vascular aging claim
The abstract frames the lipid–glucose imbalance as a driver of early vascular aging and suggests TyG assessment may refine cardiometabolic risk stratification beyond BMI. These are interpretations of observed associations, not proof of cause. Only the abstract was available; the full text was not reviewed, so details of design, follow-up and analysis cannot be checked here.
Supporting source [1]
How to interpret this
Abstract only; the full text was not reviewed. This is an observational cohort, so associations are not causes, and details of design, follow-up and analysis are not reported here.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Zang X, Wang Y, Zhang J, Lin Y, Liu X, Geng H, Liang J. · europepmc.org · April 9, 2026