Daily multivitamin slowed epigenetic aging in COSMOS trial
In the COSMOS randomized trial, 958 adults averaging 70 took a daily multivitamin or placebo for two years; the multivitamin group aged more slowly on all five epigenetic clocks, significantly on two. The creator calls the effect small and the clocks surrogate markers. [1]
Automatic summary · not editorially reviewed
The key findings
In the COSMOS trial, 958 older adults with an average age of 70 took a daily multivitamin or placebo for two years. [1]
The multivitamin group aged more slowly on all five epigenetic clocks, significantly on the two that best predict mortality, by about four months less biological aging. [1]
The creator says the effect is small and epigenetic clocks are surrogate markers, with no proof of longer life or less disease. [1]
The source at a glance
- Study type / format
- Video description of a randomized trial report.
- Population / context
- 958 older adults in the COSMOS trial, average age 70.
- Summary based on
- Creator description
- Original publication
- August 14, 2026
COSMOS trial: multivitamin versus placebo in 958 older adults
The description reports a randomized trial published in Nature Medicine. In the COSMOS trial, 958 older adults with an average age of 70 took a daily multivitamin or a placebo for two years. The comparison was therefore multivitamin versus placebo. The creator attributes the finding to this trial and links to the publication.
Supporting source [1]
Five epigenetic clocks; significant slowing on two
According to the description, researchers tracked five epigenetic clocks, described as DNA methylation measures of biological age. The multivitamin group aged more slowly on all five, significantly on the two clocks that best predict mortality, by about four months less biological aging. The creator says the benefit was greatest in people already aging faster than their birthdays.
Supporting source [1]
Creator's caveats: small effect, surrogate markers
The creator states the effect is small and that epigenetic clocks are surrogate markers: no proof of longer life or less disease, and it is unknown whether the effect persists after stopping. The description also says methylation chemistry runs on micronutrients such as folate, B12 and zinc, and that closing gaps may nudge aging itself. It labels the content education only, not medical advice, and advises talking to one's own physician before changes.
Supporting source [1]
How to interpret this
Description only; the video and transcript were not reviewed. The creator calls the effect small and the clocks surrogate markers, with no proof of longer life or less disease and unknown persistence after stopping.
Based on the creator’s description; the full video and transcript were not analyzed.
Source & supporting passages
RobertLufkinMD · youtube.com · August 14, 2026