Review: Muscle-Derived Extracellular Vesicles in Aging Interorgan Communication
This review describes skeletal muscle as a secretory organ whose extracellular vesicles carry proteins, lipids, metabolites and regulatory RNAs to other organs, and asks how aging-related changes in these vesicles may relate to inflammation, stem cell dysfunction and metabolic decline. [1]
Automatic summary · not editorially reviewed
The key findings
The review states that skeletal muscle releases extracellular vesicles that communicate with distant tissues and can modulate recipient cells in multiple organs. [1]
Aging-associated changes in vesicle formation, cargo and secretion may contribute to chronic inflammation, stem cell dysfunction, metabolic decline and age-related pathologies. [1]
The authors highlight muscle vesicles as potential biomarkers and therapeutic targets and as regulators of systemic aging and interorgan signaling. [1]
The source at a glance
- Study type / format
- Review (abstract only)
- Population / context
- Skeletal muscle and its extracellular vesicles in the context of aging, as summarized in a review
- Summary based on
- Study abstract
- Original publication
- October 1, 2026
Muscle vesicles as messengers between organs
The review starts from the idea that skeletal muscle is a secretory organ. It releases bioactive factors, including extracellular vesicles, that communicate with distant tissues. These vesicles carry diverse cargos such as proteins, lipids, metabolites and regulatory RNAs, and can change the function of recipient cells in multiple organs. The authors describe this as interorgan communication and frame muscle-derived vesicles as mediators of tissue homeostasis, regeneration, metabolism and disease progression.
Supporting source [1]
Aging-related vesicle changes and possible consequences
According to the abstract, aging is associated with alterations in how vesicles are formed, what cargo they carry and how they are secreted. Such changes may contribute to chronic inflammation, stem cell dysfunction, metabolic decline and age-related pathologies. The review also discusses effects on stem cell function and tissue regeneration and involvement in aging-related diseases. These are described as possible contributions, not proven causes.
Supporting source [1]
Biomarker and therapy hopes remain translational
The authors highlight the translational potential of muscle vesicles as biomarkers and therapeutic targets. They summarize current advances in this field and identify muscle-derived vesicles as key regulators of systemic aging and interorgan signaling. The abstract does not report new experiments, participants, follow-up times or outcome numbers, so it cannot show that influencing these vesicles changes human aging or disease.
Supporting source [1]
How to interpret this
This is an abstract of a review; the full text was not reviewed. The abstract reports no study design, sample, follow-up, outcome numbers or human intervention data, so the proposed biomarker and therapeutic roles are not established.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Jiang W, Chua K, Young J, Tan EK, Tang HW. · europepmc.org · October 1, 2026