Muscle fatigue in 8-month-old male and female hAβ-KI mice
In this abstract, isolated EDL muscle from 8-month-old male hAβ-KI mice fatigued faster than wild-type, while isolated EDL and soleus from 8-month-old female hAβ-KI mice fatigued slower; no differences appeared at 15 months. [1]
Automatic summary · not editorially reviewed
The key findings
The authors assessed skeletal muscle form and function in male and female hAβ-KI mice at 8 and 15 months, described as before and after onset of cognitive decline. [1]
At 8 months, isolated EDL muscle from male hAβ-KI mice fatigued faster than wild-type, while isolated EDL and soleus from female hAβ-KI mice fatigued slower. [1]
The authors describe the work as preliminary and suggest sex-dependent differences in isolated muscle fatigue before cognitive decline in this mouse model. [1]
The source at a glance
- Study type / format
- Preclinical mouse characterization study (abstract)
- Population / context
- Male and female hAβ-KI mice, a model of sporadic Alzheimer's disease, at 8 and 15 months of age, compared with wild-type mice.
- Summary based on
- Study abstract
- Original publication
- October 1, 2026
Aim: muscle form and function in hAβ-KI mice
The authors describe the hAβ-KI mouse as a model of sporadic Alzheimer's disease showing age-related cognitive decline and other changes. They note that skeletal muscle atrophy has been associated with cognitive decline, but whether muscle changes begin before or after cognitive decline is unclear. They therefore assessed skeletal muscle form and function in male and female hAβ-KI mice at 8 and 15 months of age, described as before and after onset of cognitive decline.
Supporting source [1]
Fatigue of isolated EDL and soleus by sex and age
Whole-body lean mass declined over time in all mice, but only male hAβ-KI mice showed a significant change in body mass and lean mass over the study. At 8 months, the isolated EDL of male hAβ-KI mice fatigued faster than that of wild-type mice. In contrast, the isolated EDL and soleus of 8-month-old female hAβ-KI mice fatigued slower than wild-type. At 15 months there were no differences, and fiber type composition did not differ at either age.
Supporting source [1]
Preliminary mouse findings, not human outcomes
The authors call this preliminary characterization work. It suggests sex-dependent differences in isolated muscle fatigue before cognitive decline in this mouse model of sporadic Alzheimer's disease. The measurements were made in isolated mouse muscles, so they do not show effects on human muscle function or on human lifespan. The abstract does not report sample sizes or how cognitive decline was timed.
Supporting source [1]
How to interpret this
Abstract only; the full text was not reviewed. Sample sizes, follow-up details and how cognitive decline was timed are not reported. Findings come from isolated mouse muscles and do not establish human outcomes.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Copeland EN, Melekh E, Fajardo VA, MacPherson REK. · europepmc.org · October 1, 2026