Self-assembled Dendrobium polysaccharide hydrogel with anti-aging activity in skin
An abstract reports a composite hydrogel of Dendrobium polysaccharide, hyaluronic acid and nicotinamide showed anti-aging effects on skin in vivo and in vitro, possibly via FOXO-linked pathways. [1]
Automatic summary · not editorially reviewed
The key findings
The abstract describes a composite hydrogel of Dendrobium polysaccharide, hyaluronic acid and nicotinamide, with hydrogen bonds and van der Waals forces as main self-assembly driving forces. [1]
The hydrogel showed anti-aging effects on skin in vivo and in vitro, including inhibited elastase/collagenase and reduced IL-6/MMP-3 expression. [1]
The authors propose the mechanism may involve FOXO and TGF-β/Smad-SIRT1 pathways and see potential for anti-aging cosmetic products. [1]
The source at a glance
- Study type / format
- Preclinical in vivo and in vitro study (abstract)
- Population / context
- Skin, studied in vivo and in vitro (species and sample details not reported in the abstract)
- Summary based on
- Study abstract
- Original publication
- October 1, 2026
Hydrogel built from Dendrobium polysaccharide, HA and NMN
The abstract describes a new composite hydrogel made from Dendrobium polysaccharide, hyaluronic acid (HA) and nicotinamide (NMN). Hydrogen bonds and van der Waals forces were reported as the main driving forces in the self-assembly of these components, and the authors say this was confirmed by isothermal titration calorimetry and molecular docking. The stated aim was to address the complexity and diversity of skin aging with a multi-target approach.
Supporting source [1]
Skin anti-aging effects in vivo and in vitro
According to the abstract, the composite hydrogel showed a strong anti-aging effect on skin both in vivo and in vitro. Reported effects include inhibition of elastase and collagenase, promotion of type I collagen secretion, prevention of reactive oxygen species, and reduced expression of IL-6 and MMP-3. The abstract does not report sample sizes, species, exposure durations or effect sizes.
Supporting source [1]
Possible FOXO-linked mechanism; cosmetic potential proposed
The abstract states that the anti-aging mechanism may be associated with FOXO and TGF-β/Smad-SIRT1 signaling pathways mediated by FOXO3, SIRT1, SMAD3 and TGF-β. The authors conclude that HA-infused composite hydrogels have potential as anti-aging cosmetic products. These are proposed mechanisms and potential uses, not established causal or clinical results; the abstract does not describe human trials or safety data.
Supporting source [1]
How to interpret this
Abstract only; the full text was not reviewed. The abstract does not report sample sizes, species, exposure durations, effect sizes, human trials or safety data, and the proposed mechanisms and cosmetic potential are not established causal or clinical findings.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Zhang Y, Wang Y, Shao H, Guo X, Xu P, Li Y, Jia J, Dong F, Hu JM, Yang L. · europepmc.org · October 1, 2026