Life's Essential 10 scores linked to mortality and CVD/cancer-free life expectancy in two US/UK cohorts
In two nationwide cohorts, higher Life's Essential 10 cardiovascular health scores were associated with lower all-cause, cardiovascular and cancer mortality and incidence, and longer life expectancy free of cardiovascular disease and cancer. [1]
Automatic summary · not editorially reviewed
The key findings
The study included 110,806 UK Biobank participants aged 37 to 73 and 20,031 NHANES participants aged 20 or older. [1]
Life's Essential 10 scores cardiovascular health from 0 to 100 and adds alcohol consumption and mental health to Life's Essential 8. [1]
Higher Life's Essential 10-based cardiovascular health levels were associated with lower all-cause, cardiovascular and cancer mortality and incidence and longer life expectancy free of cardiovascular disease and cancer. [1]
The source at a glance
- Study type / format
- Prospective observational study in two nationwide cohorts (abstract)
- Population / context
- 110,806 UK Biobank participants aged 37-73 and 20,031 NHANES participants aged 20 or older
- Summary based on
- Study abstract
- Original publication
- October 1, 2026
Two cohorts scored on Life's Essential 10
This prospective study combined 110,806 UK Biobank participants aged 37 to 73 with 20,031 National Health and Nutrition Examination Survey participants aged 20 or older. Cardiovascular health was scored from 0 to 100 using Life's Essential 10, which adds alcohol consumption and mental health to Life's Essential 8. Scores were grouped as low, and the abstract's text is cut off at that point, so the remaining categories are not reported here.
Supporting source [1]
Higher scores, lower mortality and longer healthy life
The abstract reports that higher Life's Essential 10-based cardiovascular health levels were associated with lower all-cause mortality, reduced cardiovascular and cancer mortality and incidence, and longer life expectancy free of cardiovascular disease and cancer. These are associations in observational cohorts, not evidence that raising the score causes these outcomes. The authors suggest Life's Essential 10 may offer additional targets for cardiovascular health management.
Supporting source [1]
Abstract-only scope of the two-cohort findings
Only the abstract was reviewed; the full text was not reviewed. The abstract does not report follow-up duration, how mortality and incidence were ascertained, or effect sizes and confidence intervals. It also does not give the full category definitions, because the text is cut off after the low category. The reported associations therefore cannot be quantified or adjusted for confounders from this abstract alone.
Supporting source [1]
How to interpret this
Abstract only; the full text was not reviewed. Follow-up, outcome ascertainment, effect sizes, confidence intervals and full score categories are not reported in the supplied text. Associations are not causal.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Dun Y, He L, Thomas RJ, Yang F, Ye Q, Squires RW, Olson TP, Ripley-Gonzalez JW, Wu IXY, Liu S. · europepmc.org · October 1, 2026