Sleep deprivation in young and aged mice: organ transcriptome recovery
In young and aged mice, brief sleep deprivation changed gene expression in six organs; some genes returned toward control during recovery, others drifted further. A boundary for return appeared in young testis. [1]
Automatic summary · not editorially reviewed
The key findings
Young and aged mice were briefly sleep deprived, and gene expression was profiled in six organs right after the stress and after recovery. [1]
A shape parameter distinguished genes that recovered toward control expression from those that kept drifting away during recovery. [1]
In young mice, the testis transcriptomic field contained a separatrix bounding the region from which a disturbed state can return toward control. [1]
The source at a glance
- Study type / format
- Preclinical mouse study (abstract)
- Population / context
- Young and aged mice
- Summary based on
- Study abstract
- Publication status
- Preprint · peer-review status not confirmed
- Original publication
- September 30, 2026
Sleep deprivation in young and aged mice, six organs
The study asked how molecular profiles affect a system's ability to respond to the environment. Young and aged mice were briefly deprived of sleep. Gene expression was profiled in six organs right after the stress and again after recovery. The same disturbance produced complex changes over time for each gene, and these differed by organ and by age.
Supporting source [1]
Genes that returned versus genes that drifted
A shape parameter separated two groups of genes: those that recovered toward control expression and those that continued to drift away during recovery. From these transitions the authors inferred transcriptomic vector fields, which showed distinct stability regimes across organ systems. In young mice, the testis field contained a separatrix, a boundary around the region from which a disturbed state can return toward control.
Supporting source [1]
Abstract-only scope of the mouse transcriptome study
This explainer is based on the abstract only; the full text was not reviewed. The abstract does not report sample sizes, the length of sleep deprivation or recovery, or how strongly the findings varied between animals. The results are gene-expression patterns in mice, not evidence about human health or lifespan. The authors present transient disturbance and recovery as a framework for studying age-dependent stability.
Supporting source [1]
How to interpret this
Abstract only; the full text was not reviewed. Sample sizes, stress and recovery timing, and variability between animals are not reported in the abstract. Findings are mouse gene-expression patterns, not human outcomes.
Based on the study abstract; the full paper, tables and supplementary data were not reviewed.
Source & supporting passages
Xu B, Ji S, Lin Z, Deng C, Li L. · europepmc.org · September 30, 2026