RAPAMYCIN: How Easter Island Led To The Discovery of the mTOR Pathway [2021]

👉 More longevity bioacks. Join my free community: https://www.skool.com/the-longevity-alliance/about Reading medical studies and boning up on longevity makes for some dry reading. Not so with the discovery story of rapamycin and the mTOR pathway. Today's video is a 2-parter. The first part is the history of rapamycin and it's a tale with exotic locales and not one resurrection, but two; one from the last place you'd think. The second part of this video takes a good look at several studies of rapamycin, both past and present. And we'll examine rapamycin's role in the age-related decline in immunity and loss of muscle mass. I'll admit it. I've never been a big fan of taking rapamycin to inhibit the mTOR pathway and possibly extend lifespans. But these studies have reset my thinking, and I may be changing my mind. Chapters & Timestamps: 00:00 Intro 00:50 The Story of Rapamycin 05:30 Rapamycin Studies 10:21 Rapamycin & Immunosuppression 11:55 Rapamycin & Sarcopenia 14:52 Conclusions Links to studies referred to in this video: Rapamycin extends lifespans in mice: https://www.nature.com/articles/nature08221 Opinion article on Rapamycin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/ Rapamycin and the quest to slow aging through drug discovery: https://pubmed.ncbi.nlm.nih.gov/32467649/ Rapalogs and COVID-19: https://pubmed.ncbi.nlm.nih.gov/33665645/ Rapamycin, sarcopenia and aging muscle: https://pubmed.ncbi.nlm.nih.gov/31454792/ ************************************************************** SOCIAL MEDIA LINKS: Facebook: https://www.facebook.com/lancehitchings/ Instagram: https://www.instagram.com/lancehitchings/ Twitter: https://twitter.com/LanceHitchings ************************************************************** AFFILIATE LINKS: Discount code for DoNotAge: LANCE Product Links for DoNotAge: Annual Subscription: https://donotage.org/subscribe/ Products : https://donotage.org/products/ Discount code for Alive By Science: LANCE10 Product Links: https://alivebyscience.com/all-products-by-delivery-method/ Discount Code for Perfect Amino: HITCH10 PerfectAmino Drink Powder link: http://affiliates.bodyhealth.com/idevaffiliate.php?id=926&url=91 PerfectAmino Tablets link: http://affiliates.bodyhealth.com/idevaffiliate.php?id=926&url=92