PI3K–Akt–mTOR Signaling Pathway Explained | Cell Growth, Survival & Protein Synthesis
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PI3K–Akt–mTOR Signaling Pathway Explained | Cell Growth, Survival & Protein Synthesis
Understand the PI3K–Akt–mTOR Signaling Pathway in a simple and visual way with this easy-to-follow biology animation. The PI3K–Akt–mTOR pathway is one of the most important cell signaling pathways that regulates cell growth, metabolism, protein synthesis, survival, proliferation, and autophagy. It is activated when growth factors such as insulin or IGF bind to receptor tyrosine kinases (RTKs), initiating a signaling cascade through PI3K, Akt, and mTOR. This pathway plays a central role in normal physiology and is frequently dysregulated in cancer, diabetes, aging, and metabolic diseases.
In this video, the PI3K–Akt–mTOR signaling pathway is explained step by step using a clear schematic animation, making it easy to understand how extracellular growth signals regulate cellular metabolism and growth. This pathway is essential for learning molecular biology, cell biology, cancer biology, and biochemistry.
In this video, you will learn:
• What the PI3K–Akt–mTOR signaling pathway is
• How growth factors activate receptor tyrosine kinases (RTKs)
• The role of PI3K in intracellular signaling
• Conversion of PIP2 into PIP3
• Activation of Akt (Protein Kinase B)
• How mTOR regulates protein synthesis and cell growth
• The role of PI3K–Akt–mTOR signaling in metabolism and cell survival
• Regulation of autophagy by mTOR
• Clinical significance of the PI3K–Akt–mTOR pathway in cancer and diabetes
• Frequently asked examination concepts related to cell signaling
This video is especially useful for students preparing for:
• NEET
• CUET
• CSIR NET Life Sciences
• GATE Life Sciences
• DBT BET
• ICMR JRF
• UGC NET
• BSc Biotechnology
• MSc Biotechnology
• BSc Microbiology
• MSc Microbiology
• Cell Biology, Molecular Biology, Biochemistry, Cancer Biology, and Pharmacology courses
If you're looking for high-quality biology animations, molecular biology tutorials, biotechnology lectures, cancer biology concepts, immunology videos, and life science exam preparation, this channel provides clear, engaging, and scientifically accurate explanations that simplify complex biological pathways.
Continue exploring our videos on receptor-mediated signaling, insulin signaling, MAPK/ERK signaling, GPCR signaling, JAK-STAT pathway, TLR4 signaling, apoptosis, mTOR signaling, molecular biology, cell biology, biotechnology, microbiology, genetics, cancer biology, and biochemistry.
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Dr. Lokender Kumar · 2 min · Source published: 2026-09-05
Added to Harbor: 10/22/2026
Original on YouTube ↗Automatically categorized source. Creator statements are not an independent evidence review or personal medical guidance.