Senescent Cell Expert : Big Pharma Walked Away, But The Future Is Bright

Senescent cells were supposed to be the "easy" target in aging research—clear them out and extend healthspan. But new research reveals the field is far more complex than anyone imagined, with major clinical trial setbacks forcing scientists to completely rethink their approach. Some links are affiliate links so we will earn a commission when they are used to purchase products. I--------------------- If you would like to support our channel please consider joining our Patreon https://patreon.com/ModernHealthspan *Renue By Science* (10% off: MHS) https://tinyurl.com/bdew4bfs NMN Powder • Lipo NR *BiOptimizers* (15% off: Modern10) https://bit.ly/42OqRVW - Magnesium Breakthrough *Stemregen* (15% off: MODERN) *US only* https://tinyurl.com/45z968yr *Qualia* (15% off: MODERN) Senolytic: https://tinyurl.com/22t9thrn • Mind: https://tinyurl.com/5hatj2t2 *Life Extension* ($10 off $50 order) NAC: https://tinyurl.com/vzvbde99 • Ergothioneine 25mg https://tinyurl.com/48h2bnst *NOVOS* ($5 off: 5OFFMHS24) https://novos.sjv.io/QyWP7o, https://novos.sjv.io/NOVOS *n1o1* (10% off: Modern) https://tidd.ly/3IczGRW - Nitric Oxide Lozenges *Wellness Extract* (10% off: MODERNWE) http://wellnessextract.com/RICHARDWE Geranylgeraniol • Vit E *AX3 Life* (20% off: MODERN20) https://ax3.life/MODERN20 - Astaxanthin *Oxford Healthspan* (15% off: MHS) https://tinyurl.com/hrxfnzpn - Spermidine *Nuchido* (20% off first order: MODERN20) https://nuchido.com/MODERN - Time+ --------------------- In this conversation with Dr. Paul Robbins from the University of Minnesota, we explore the evolving world of senescent cell research and senolytics—drugs designed to clear "zombie" cells from our bodies. Dr. Robbins reveals how recent research shows senescence is far more complex than expected, with different types arising from different stresses. We discuss why Unity Biotech's trials failed, mixed results from fisetin studies, and surprising positive signals from Mayo Clinic trials in patients with high senescent cell burden. He explains why future treatments will require personalized cocktails of different senolytics, the potential of alternative approaches, and why he remains optimistic despite setbacks. 📚 Chapters 00:00 How Senescent Cell Research Has Changed 03:02 Are Senescent Cells Essential for Rejuvenation? 05:11 The Fisetin ITP Trial: What Went Wrong? 08:47 Unity Biotech's Clinical Trial Results 13:52 Hidden Positive Signals in Human Trials 16:17 The Challenge of Identifying Senescent Cells 23:10 Should We Remove ALL Senescent Cells? 26:22 Next-Generation Senolytics and Cocktail Approaches 37:41 Senomorphics: Suppressing the Bad Without Killing Cells 41:19 Reversing Senescence: Promise and Perils 49:19 The Future of Senescent Cell Research 🌐Links in this video PAPERS & TRIALS Fisetin at the ITP Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used https://pmc.ncbi.nlm.nih.gov/articles/PMC10828146/ Bone strength trial Targeting Cellular Senescence With Senolytics to Improve Skeletal Health in Older Humans https://clinicaltrials.gov/study/NCT04313634 Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD) Study (SToMP-AD) https://www.clinicaltrials.gov/study/NCT04685590 Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00046-4/fulltext Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age https://pmc.ncbi.nlm.nih.gov/articles/PMC9924942/ WEBSITES SenNet Consortium https://sennetconsortium.org/ Rubedo Life Sciences https://www.rubedolife.com/ Translational Geroscience Network https://www.gerosciencenetwork.org/ Masonic Institute on the Biology of Aging and Metabolism (MIBAM) https://med.umn.edu/aging Nathan Shock https://nathanshockcenters.org/ *************************************** Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. Please consult with your doctor first. Products or services mentioned in this video are not a recommendation. Audio Copyright Disclaimer Please note that we have full authorization to the music that we used in our videos as they were created using the service WeVideo which provides the rights to the music. The rights are detailed in the terms of use that can be reviewed here https://www.wevideo.com/terms-of-use and any following inquiries should be addressed to legal@wevideo.com. #longevity #senescentcells #antiaging