The Rapamycin Paradox

Article: R Mahalakshmi, R., Priyanga, J., Bhakta-Guha, D., Guha G., 2022. Hormetic effect of low doses of rapamycin triggers anti-aging cascades in WRL-68 cells by modulating an mTOR-mitochondria cross-talk. Mol. Biol. Rep. 49(1), 463-476. DOI: 10.1007/s11033-021-06898-6 About the Article: This research explores how low doses of the drug rapamycin can trigger anti-aging effects by improving the health and density of mitochondria, the tiny "powerhouses" of the cell. Unlike toxic high doses, these smaller amounts help reduce oxidative damage and prevent cellular decline by fine-tuning the communication between specific metabolic pathways. This discovery suggests that precisely managing this internal "cross-talk" can keep cells functional and resilient as they age. Institution: School of Chemical & Biotechnology (SCBT) SASTRA University Sustainable Development Goals (SDGs) SDG 3 – Good health and well-being Disclaimer: This video summary has been generated using AI tools based on the published research article. AI-generated summaries may contain simplifications or inadvertent inaccuracies. This material is intended solely for broad dissemination and public engagement of research. For scholarly, academic, or technical use, readers must consult the original published article. The original publication remains the authoritative source.