EnsembleAge: Epigenetic Clocks for Aging and Rejuvenation Research

The link to the original article: https://link.springer.com/article/10.1007/s11357-025-01808-1 Key-words: Epigenetic clocks, Biological age, MethylGauge dataset, EnsembleAge, DNA methylation, Aging biomarkers, Healthspan, Lifespan interventions, Mouse models, Stress response, Rejuvenation, Cross-species analyses, Penalized models, Robustness, Translational research, Human studies, Longevity interventions, Reduced Representation Bisulfite Sequencing (RRBS), Multi-tissue clocks, Caloric restriction, Mammalian Methylation Array, Illumina Infinium platform, CpG sites, Elastic net regression, Ridge regression, Lasso regression, Standardization, Benchmarking datasets, Perturbation experiments, EnsembleAge.Dynamic, EnsembleAge.Static, Genetic disease models, Huntington’s disease, Hutchinson Gilford progeria, Yamanaka factors, Epigenome-wide association studies (EWAS), Chronological age, Mean square error (MSE), Cross-validation, Accuracy, Sensitivity, Specificity, Time to death, Promoter regions, 5’UTRs, CpG islands, Gene set enrichment, Chromatin state, Transcription factors, Precision medicin