Why Fasting Activates Autophagy - Your Body's Internal Repair System?

What happens inside your body when you stop eating for 16, 18, or 24 hours? The answer involves autophagy, one of the most important cellular repair mechanisms ever discovered. In this video, we explore the science of fasting, autophagy, mTOR, AMPK, cellular recycling, longevity, aging, metabolism, protein clearance, brain health, and the Nobel Prize-winning research that revealed how your cells remove damaged proteins and worn-out cellular components. Learn why fasting triggers a shift from growth mode to maintenance mode, how autophagosomes and lysosomes work, what happens to damaged mitochondria, and why researchers are studying autophagy's role in Alzheimer's disease, Parkinson's disease, healthy aging, metabolic health, and lifespan. The biology behind skipping meals is far more fascinating than most people realize—and your body has been doing it your entire life. If you enjoy evidence-based biology, longevity science, neuroscience, metabolism, aging research, and deep dives into how the human body actually works, subscribe and turn on notifications. New videos every week explaining the hidden mechanisms behind health, disease, aging, fasting, brain function, exercise, and human biology. Sources Nobel Prize Outreach AB. The Nobel Prize in Physiology or Medicine 2016 awarded to Yoshinori Ohsumi for discoveries of mechanisms for autophagy. Ohsumi Y. Historical landmarks of autophagy research. Cell Research. 2014. Mizushima N, Komatsu M. Autophagy: Renovation of Cells and Tissues. Cell. 2011. Levine B, Kroemer G. Biological Functions of Autophagy Genes. Cell. 2019. Klionsky DJ et al. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy. Autophagy Journal. De Duve C. The Lysosome Revisited. Scientific American. Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR Regulate Autophagy Through Direct Phosphorylation of Ulk1. Nature Cell Biology. Alirezaei M et al. Short-Term Fasting Induces Profound Neuronal Autophagy. Autophagy. Rubinsztein DC et al. Autophagy and Aging. Cell. Hansen M, Rubinsztein DC, Walker DW. Autophagy as a Promoter of Longevity. Nature Reviews Molecular Cell Biology. Madeo F et al. Caloric Restriction Mimetics Against Age-Associated Disease. Cell Metabolism. Menzies FM, Fleming A, Rubinsztein DC. Compromised Autophagy and Neurodegenerative Diseases. Nature Reviews Neuroscience.