Ora Biomedical video: 10,000 longevity experiments, peptides and resilience

Subscribe to our channel: https://www.youtube.com/@mkaeberlein What can we learn from the first 10,000 experiments in the search for interventions that extend healthy lifespan? In this episode of Longevity Science, I sit down with Dr. Ben Blue, CEO of Ora Biomedical, and Dr. Blair Zhao, CSO, for an update on Ora’s effort to systematically screen interventions for effects on lifespan and healthspan. We start with the Million Molecule Challenge and some intriguing new results from a screen of roughly 300 peptides, including known peptides, AI-predicted candidates, and structurally diverse molecules. We discuss what Ora is beginning to learn from nearly 10,000 intervention experiments, why existing datasets may not be sufficient to predict longevity therapeutics with AI, and how large-scale experimental data could eventually change that. We also explore an unexpected direction emerging from these experiments: resilience. Rather than asking only whether a molecule extends lifespan, can longevity interventions improve the body's ability to recover from damage? That question has led Ora from lifespan studies in C. elegans to UV and radiation resistance, human skin cells, animal studies, and potential applications ranging from photoaging and cancer radiation therapy to protecting pilots and astronauts from radiation exposure. Along the way, Ben and Blair share early results from Ora’s pipeline, including a longevity-associated compound that reduced radiation dermatitis burden by approximately 40% in a mouse model, as well as work on natural products that may improve recovery from UV damage. We also discuss the challenge of translating discoveries from worms into humans and whether resilience could provide a practical path for testing longevity therapeutics on a much shorter timescale. Disclosure: I am a co-founder of Ora Biomedical and serve on its Board of Directors. I have a financial interest in the company. This relationship is disclosed so viewers can appropriately consider this potential conflict of interest when evaluating the discussion. Topics include: the Million Molecule Challenge, AI and longevity drug discovery, peptide therapeutics, C. elegans, mTOR, stress resilience, UV damage, radiation therapy, skin aging, natural products, astronauts and spaceflight, and translating longevity interventions to humans. DISCLAIMER: The information provided on this channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find me: Instagram: https://www.instagram.com/mkaeberlein/ LinkedIn: https://www.linkedin.com/in/mkaeberlein/ Twitter: https://twitter.com/mkaeberlein Facebook: https://www.facebook.com/matt.kaeberlein/ --- Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this channel I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!