Actionable Interventions in Human Aging: Insights from ARDD 2025 | Aging-US

Aging-US #published this #meetingreport on April 6, 2026, in Volume 18, titled “Toward actionable interventions in human aging (12th ARDD meeting, 2025)" led by corresponding authors Aleksandr Dekan and Daniela Bakula from the Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark. @ardd3628 #aging #longevity #geroscience #biomarkers #meeting #openaccess #openscience #PaperSpotlight #peerreview #journal #publishing #meded DOI - https://doi.org/10.18632/aging.206368 Corresponding authors - Aleksandr Dekan - adekan@sund.ku.dk, and Daniela Bakula - bakula@sund.ku.dk Abstract The 12th Aging Research and Drug Discovery (ARDD) meeting convened at the University of Copenhagen, presenting a comprehensive overview of recent advancements in the biology of aging. A central theme across sessions was the field’s gradual shift from descriptive, correlational studies to mechanistic understandings enabling the engineering of personalized therapeutic interventions aimed at extending human healthspan. Key discussions highlighted the convergence of multiple disciplines. Presentations detailed how fundamental biological insights are being integrated with artificial intelligence and machine learning platforms for accelerated target identification and drug development. Furthermore, the development and application of novel preclinical research models were presented as critical for improving the translational pipeline to human clinical trials. Scientific discourse has advanced from cataloging the established hallmarks of aging to identifying and modulating the specific molecular mechanisms that regulate them. This focus is predicated on the hypothesis that aging is not solely a result of stochastic damage accumulation but may be a tractable, modifiable, and potentially reversible biological process amenable to intervention. This report summarizes the principal research directions and conceptual frameworks presented at the conference. Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206368 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, longevity, geroscience, biomarkers, rejuvenation To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM