Aging Biomarkers, Senolytics, and Health Span | Matt Yousefzadeh | Medicine 3.0 Ep. 13

How do aging biomarkers actually work — and which ones matter right now? In this episode, Dr. Jared Pelo sits down with Matt Yousefi of Columbia University Medical Center to talk about the science of aging, senolytics, and the biomarkers researchers are using to better understand health span and biological aging. Matt explains how he moved from cancer research into aging science, why biomarkers are so important in this field, and how researchers think about biological age versus chronological age. They also discuss cellular senescence, inflammation, DNA damage, epigenetic clocks, exercise, caloric restriction, and why the field still has more questions than answers. Topics covered in this video: What biomarkers of aging are Biological age vs. chronological age Senolytics and cellular senescence DNA damage and inflammation in aging Epigenetic clocks and methylation testing Exercise, caloric restriction, and aging research Why health span matters more than lifespan Which aging biomarkers may be most useful today This episode is for viewers interested in longevity science, aging biomarkers, senolytics, and the research shaping the future of healthy aging.