SIRT6, DNA Repair & the Dark Genome | Professors Vera Gorbunova & Andrei Seluanov

SIRT6Activator® is 1 of the 15 longevity ingredients in DoNotAge®: https://routine.donotage.org/donotage Why does a naked mole rat live more than 40 years while a mouse lives two or three? And what does that tell us about healthy ageing in humans? At the DoNotAge.org Conference 2026 in London, Professors Vera Gorbunova and Andrei Seluanov of the University of Rochester share decades of research into DNA repair, the "dark genome" and the inflammation that drives ageing. Professor Gorbunova explains: Why genomic instability and epigenetic disorganisation sit at the root of many hallmarks of ageing How SIRT6, a key DNA repair protein, is more active in long-lived species and in some human centenarians Her lab's work on fucoidan from brown seaweed, including batch testing of SIRT6Activator®, and findings in ageing mice on frailty, epigenetic age and lifespan A clinical trial in older adults now under way in Singapore, supported in part by DoNotAge.org Professor Seluanov explores: Inflammageing: the low-grade chronic inflammation that builds up with age The "dark genome": why around half of our DNA is made up of transposable elements, and how LINE-1 elements reactivate as we age Research in mice showing that suppressing LINE-1 reduced inflammation and frailty What's next, including new research into safer compounds that target transposons The session closes with a plain-English summary from DoNotAge.org founder Alan Graves. Chapters 0:00 What causes ageing? The hallmarks of ageing 2:24 Genomic instability and the epigenetic "sock drawer" 4:20 SIRT6: a longevity gene 6:08 Why long-lived species repair DNA better 9:14 Boosting SIRT6 in cells and mice 11:46 Fucoidan and brown seaweed 14:10 Testing fucoidan batches: SIRT6Activator® 15:48 Fucoidan in ageing mice 18:12 The Singapore clinical trial 19:18 Professor Andrei Seluanov: inflammageing 24:58 The dark genome and LINE-1 28:22 Repurposing antiviral drugs to block transposons 34:02 Reducing LINE-1 in mice: less inflammation, less frailty 38:00 Epigenetic clocks and new compounds in development 40:38 Session summary with Alan Graves 🔬 Learn more about SIRT6Activator®: https://donotage.org/sirt6-activator DoNotAge.org is a Health Research Organisation on a mission to extend the healthy lifespan of as many people as possible. #Longevity #HealthyAgeing #SIRT6