The Mitochondrial Genome as a Hard Limit to Mammalian Lifespan
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The link to the original article: https://www.biorxiv.org/content/10.1101/2025.06.03.656903v1.full.pdf
Key-words: IGF-1 signaling, longevity, lifespan, mitochondrial genome, mtDNA, aging, hallmarks of aging, mitochondrial mutator mice, genomic instability, mitochondrial dysfunction, nutrient sensing, mitochondrial mutagenesis, sarcopenia, neurodegeneration, heart failure, cardiovascular disease, oxidative stress, PolgA D257A, DNA Polymerase , cardiomyopathy, Pappa, Pappalysin 1, proteostasis, DNA repair, telomere maintenance, splenomegaly, anemia, inflammation, cytokines, grip strength, endurance, cardiac hypertrophy, echocardiography, duplex sequencing, clonal expansion, homoplasmy, COX/SDH activity, transcriptomic profiling, metabolic flexibility, gluconeogenesis, adipokines, mTOR signaling, epigenetic, chromatin, heat shock proteins, lipid metabolism, healthspan, geroprotective, IGFBP-4, catabolic metabolism
The Sanz Science Experience · 15 min · Source published: 2025-09-16
Added to Harbor: 10/22/2026
Original on YouTube ↗Automatically categorized source. Creator statements are not an independent evidence review or personal medical guidance.