BEN BIKMAN a3 | AUTOPHAGY DECLINES w/ AGE …rapamycin may help, but lots of side effects
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Creator description · original textText language: English
http://www.DoctorsToTrust.com
@doctorstotrust
presents episode 2477 | DR BEN BIKMAN w/Metabolic Classroom
Autophagy and longevity: research and hype…
-the control of chronic diseases helps us with longevity
-research shows that autophagy effectiveness declines with age
-inability of a cell to rid itself of damaged components, is aging
Enhancing autophagy increases lifespan & healthspan in
a handful of organisms
in mice: genetic overexpression of
ATG5 enhances autophagy—
leading to expanded lifespan &
improved muscle & brain health
Rapamycin, mTOR inhibitor…
mTOR is an important cellular protein complex that only wants
to build up molecules [autophagy wants to break down]
-when mTOR on, autophagy is off
When rapamycin turns mTOR off, it turns autophagy on
[check: https://youtu.be/Rriqri86jpw]
to learn positives & negatives
Rapamycin: all studies are on animal or insects…
-in germ free, sterile facilities
-nothing to affect the immune system
-all organisms studied were all exactly the same
Rapamycin may give immune system compromises &
muscle recovery issues
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original video here: https://youtu.be/Er1MVXUOJh8?si=3QaerNdRZy4_QZ-U
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DoctorsToTrust · 6 min · Source published: 2025-01-26
Added to Harbor: 10/30/2026
Original on YouTube ↗Automatically categorized source. Creator statements are not an independent evidence review or personal medical guidance.