Rapamycin’s Anti-Alzheimer’s Promise: An Autophagy Story

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]* Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]* Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy *JOIN THE COMMUNITY* Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2 *EMAIL LIST* 1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6 *HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender 0:00 - Introduction 0:30 - Rapamycin's Proposed Anti-Alzheimer's Effects 3:05 - Does Rapamycin work on Alzheimer's Disease? 5:31 - How does Rapamycin achieve these effects? 8:01 - Take-aways 9:05 - Why is autophagy also increased in Alzheimer's Disease? 10:22 - A Twist to the Story... References [Study 355] Kaeberlein M, Galvan V. Rapamycin and Alzheimer's disease: Time for a clinical trial?. Sci Transl Med. 2019;11(476):eaar4289. doi:10.1126/scitranslmed.aar4289 Funding/Conflicts: Public Funding [University of Washington, National Institute of Health] // Potential Conflicts of Interest [Scientific Advising for Resterobio Inc.] [Study 356] Hou SJ, Zhang SX, Li Y, Xu SY. Rapamycin Responds to Alzheimer's Disease: A Potential Translational Therapy. Clin Interv Aging. 2023;18:1629-1639. Published 2023 Oct 2. doi:10.2147/CIA.S429440 Funding/Conflicts: Public Funding [Shanxi Provincial Health Commission, Doctoral Fund] // No Potential Conflicts of Interest [Study 357] Wang H, Fu J, Xu X, Yang Z, Zhang T. Rapamycin Activates Mitophagy and Alleviates Cognitive and Synaptic Plasticity Deficits in a Mouse Model of Alzheimer's Disease. J Gerontol A Biol Sci Med Sci. 2021;76(10):1707-1713. doi:10.1093/gerona/glab142 Funding/Conflicts: Public Funding [National Natural Science Foundation of China] // No Conflicts of Interest ********CRITIQUES, RULES, AND NOTES******** Be aware of the following rules before posting comments: - Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce). Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique: Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached. RULES: If your comment is rude, you will be banned. If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response. If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!). Please use the following link to submit your critique: https://bit.ly/PhysionicCritique Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes. #alzheimersprevention #alzheimersresearch #alzheimerscare