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Video library· Dr. Joanette MDAudio: American English

Video description compares NMN, NR and nicotinamide and asks whether raising NAD+ improves health

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At a glance

Automatic summary · not editorially reviewed

The description says the video covers a first direct comparison of NMN and NR, plus nicotinamide, and stresses that a higher blood number is not the same as better health. All claims come from the description; video and transcript were not reviewed. [1]

  1. The description says the video presents the first direct comparison of NMN and NR, with a timestamp naming a trial of NMN versus NR versus plain nicotinamide. [1]

  2. The description says gut bacteria are doing the real work in the described mechanism. [1]

  3. The description stresses that a higher measured number is not the same as improved health. [1]

Described NMN, NR and nicotinamide comparison

The description says researchers in Switzerland, Japan and some US university hospitals ran the same tests on two competing longevity vitamins, and that nobody had put them head to head until now. It calls the video the first direct comparison of NMN and NR. A timestamp lists a new head-to-head trial of NMN versus NR versus plain nicotinamide. The description also says earlier trials already supported this pattern. These are the creator's characterizations; the video itself was not reviewed. [1]

Described gut-bacteria mechanism and blood-marker caution

A timestamp promises a surprising mechanism in which gut bacteria do the real work. The description repeatedly separates raising a number in the blood from improving health: one timestamp asks whether raising the number actually improves health, another says the number going up is not the same as the problem being solved. It also mentions lab numbers versus how you feel and what these trials can and cannot measure. The description does not report effect sizes, participant numbers or which outcomes changed. [1]

Described unknowns and creator's practical framing

The description includes a timestamp on being fair to the science and what is still unknown, and one on whether viewers should switch or keep taking either supplement. It also points to what actually moves the needle on healthy aging. The creator presents herself as an emergency medicine physician and founder of a practice, and offers help fitting such findings into personal health goals. The description lists referenced studies, including a preprint not yet peer-reviewed, but gives no results from them. [1]

Context & limits

Only the video description was available; the video and transcript were not reviewed. The description gives no participant numbers, effect sizes or outcome results, and its study references include a preprint not yet peer-reviewed. Claims are the creator's characterizations, not verified findings.

Based on the creator’s description; the full video and transcript were not analyzed.

[1] NMN vs. NR vs. NAD+: Which One Actually Works?
Quoted passages in the original language
the first direct comparison of NMN and
your gut bacteria are doing the real
isn't the same thing as improving your

About this video

Creator description · original textText language: American English

NMN vs NR: what does the data actually show? We examine the latest side-by-side test results for these vitamins. Right now, researchers in Switzerland, Japan, and a few US university hospitals have been running the same tests on two competing "longevity vitamins," and nobody had ever put them head to head until now. In this video I walk through the first direct comparison of NMN and NR, what it actually found, and why raising a number in your blood isn't the same thing as improving your health. Welcome to Dr. Joanette MD Hi, I'm Dr. Joanette, an ER doctor, Blue Zone native, and founder of Optimum Health MD. I blend decades of emergency medicine experience with modern longevity science to bring you practical, evidence-based insights that help you live stronger, longer. Everyone is welcome here. Dr. Joanette's Bio I'm the founder of Optimum Health MD, dedicated to optimizing health and longevity. I graduated from New York Medical College in 1995 and am board-certified in Emergency Medicine. I'm licensed to practice in the states of California and New York. This channel is separate from my duties as attending medical staff at Saint John's Riverside Hospital and as an assistant professor at Albert Einstein College of Medicine and Lake Erie College of Medicine. The views expressed on this channel are my own. TIMESTAMPS: 0:00 – The quiet head-to-head competition between two "longevity vitamins" 0:24 – What NMN and NR actually are, and why this new data matters 0:51 – Dr. Joanette's background 1:34 – Addressing the pushback from her earlier "Why I Stopped Taking NMN" video 2:15 – Lab numbers vs. how you feel: what these trials can and can't measure 3:36 – The basics: what NAD+ actually is, and why you take the precursors instead 4:20 – The new head-to-head trial: NMN vs. NR vs. plain nicotinamide 5:22 – The surprising mechanism: your gut bacteria are doing the real work 6:01 – Earlier trials that already supported this pattern 6:50 – The bigger question: does raising the number actually improve your health? 7:56 – What the pooled outcome data actually shows 8:33 – Why "the number went up" isn't the same as "the problem is solved" 9:20 – Being fair to the science: what's still unknown 9:49 – Dr. Joanette's actual take: should you switch, or keep taking either one? 10:53 – What actually moves the needle on healthy aging 11:33 – Get a personalized plan with Optimum Health MD STUDIES REFERENCED: 1. Christen S, Redeuil K, Goulet L, et al. "The Differential Impact of Three Different NAD+ Boosters on Circulatory NAD and Microbial Metabolism in Humans." Nature Metabolism. 2026;8:62–73. https://doi.org/10.1038/s42255-025-01421-8 2. Chen F, Zhou D, Kong APS, et al. "Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-Analysis of Randomised Controlled Trials." Current Diabetes Reports. 2024;25(1):4. https://doi.org/10.1007/s11892-024-01557-z 3. Zhang J, Poon ETC, Wong SHS. "Efficacy of Oral Nicotinamide Mononucleotide Supplementation on Glucose and Lipid Metabolism for Adults: A Systematic Review with Meta-Analysis on Randomized Controlled Trials." Critical Reviews in Food Science and Nutrition. 2025;65(22):4382–4400. https://doi.org/10.1080/10408398.2024.2387324 4. "Mapping Evidence Gap Between NMN and NR for Metabolic Outcomes: A Systematic Review, Transitivity Assessment, and Indirect Comparison Meta-Analysis." Preprint, bioRxiv, 2026. Not yet peer-reviewed. 📌 If you want help figuring out where something like this actually fits into your own health picture, your labs, your goals, what's actually worth your money, that's the work we do at Optimum Health MD, the practice I founded. Thanks for joining me today, and I'll see you next time. DISCLAIMER: As a physician passionate about health education, I want to be clear that while I share evidence-based information, I am not your personal doctor and don't know your unique medical history. The recipes and wellness tips I provide are for educational purposes only. Before making any dietary or lifestyle changes based on my content, please consult with your healthcare provider, who understands your specific health needs and can offer personalized guidance. Your well-being matters, and I'm here to support your health journey alongside the care you receive from your medical team. #NMN #NR #NAD #Longevity #AntiAging #ERDoctor #OptimumHealthMD #SupplementScience #HealthyAging #Biohacking Don’t forget to subscribe for more health tips and recipes! @DrJoanette Website: https://optimumhealthmd.com/ Follow for More! TikTok: https://www.tiktok.com/@drjoanette LinkedIn: https://www.linkedin.com/in/drjoanetteweissemd

Dr. Joanette MD · 14 min · Source published: 2026-09-21

Added to Harbor: 10/23/2026

Original on YouTube ↗

Automatically categorized source. Creator statements are not an independent evidence review or personal medical guidance.

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