The Clinical Trials That Could Transform Longevity Medicine

Subscribe to our channel: https://www.youtube.com/@mkaeberlein How do we move from promising aging research to actual medicines that improve human health? In Part 2 of my conversation with Dr. Brianna Stubbs, scientist at the Buck Institute for Research on Aging, we leave the world of ketones behind and explore one of the biggest challenges facing the longevity field: how to translate discoveries in aging biology into therapies that can be tested, approved, and ultimately reach patients. Brianna leads an ambitious clinical research program at the Buck Institute and is involved in multiple large-scale studies funded by the NIH, ARPA-H, the Department of Defense, and philanthropic organizations. We discuss how these clinical trials are helping build the future of longevity medicine—from developing better biomarkers of aging to creating entirely new regulatory pathways for gerotherapeutics. Topics include: Why measuring aging is one of the field's biggest challenges The Buck Institute's expanding clinical research program ARPA-H's ambitious vision for transforming longevity medicine The search for reliable biomarkers of healthy aging Wearables, AI, and digital biomarkers The concept of "intrinsic capacity" and why it could reshape aging medicine The path toward FDA approval for gerotherapeutics Clinical trials on frailty, metabolism, exercise, and healthy aging What we can learn from elite athletes and other unique populations Why recruitment is often the biggest obstacle in clinical research The future of decentralized clinical trials This conversation offers a behind-the-scenes look at how the next generation of longevity interventions may be developed, tested, and ultimately brought into clinical practice. Guest: Dr. Brianna Stubbs, PhD Scientist, Buck Institute for Research on Aging Subscribe to Longevity Science for evidence-based conversations exploring the biology of aging, geroscience, longevity medicine, and the science behind extending healthspan. #Longevity #HealthyAging #Geroscience #ClinicalTrials #BuckInstitute #ARPAH #Healthspan #LongevityMedicine #AgingResearch #Biomarkers #Wearables #PrecisionMedicine #SciencePodcast #LongevityScience DISCLAIMER: The information provided on this channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find me: Instagram: https://www.instagram.com/mkaeberlein/ LinkedIn: https://www.linkedin.com/in/mkaeberlein/ Twitter: https://twitter.com/mkaeberlein Facebook: https://www.facebook.com/matt.kaeberlein/ --- Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this channel I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!