The Naked Mole-Rat's Secret to Longevity Lies in DNA Repair Machinery

The link to the original paper: https://www.science.org/doi/epdf/10.1126/science.adp5056 Key-words: AAV (Adeno-associated viruses), Aging, Amino acid residues, BRCA1, CB-5083 (P97 inhibitor), cGAS (cyclic GMP-AMP synthase), cGAMP (cyclic GMP-AMP), Cell cycle, Cellular senescence (SIPS), Chimeric cGAS, Chromatin binding, Climbing assay, co-IP (coimmunoprecipitation), Comet assay, DNA damage, DNA repair, DSBs (DNA double-strand breaks), Drosophila, E3 ubiquitin ligase, ELISA (Enzyme-linked immunosorbent assay), Etoposide, FACS (Fluorescence-activated cell sorting), FANCI (repair factor), Fanconi anemia (FA) pathway, Frailty index, Genomic instability, GSEA (Gene set enrichment analysis), Gut permeability, HCA2-hTERT cells, Heterocephalus glaber, Homologous recombination (HR), Human cGAS, Immunoglobulin G (IgG), Immunostaining, Innate immune responses, Interleukin-6 (IL-6), Intestinal stem cell (ISC), K48-linked ubiquitination, Life span, Longevity, Mass spectrometry, Naked mole-rat, P97 (segregase), p21 (senescence marker), PARP1, PLA (Proximity ligation assay), RAD50 (repair factor), RAD51 (recombinase), RNA-seq (RNA sequencing), TRIM41 (E3 ubiquitin ligase)