When Mitochondrial DNA goes Nuclear

The original review: https://doi.org/10.1016/j.arr.2025.102892 Key-words: 8-oxo-deoxyguanosine, aging, altered cellular communication, apoptosis, BAX/BAK pore, biological aging, carcinogenesis, cellular senescence, chromosomal instability, cognitive decline, cGAS-STING, D-loop, DNA double-strand breaks, DNA repair, DNA methylation, endosymbiosis, epigenetic alterations, evolutionary conservation, gasdermin D, genomic instability, geroscience, hallmarks of aging, horizontal gene transfer, humanin, immunosenescence, inflammaging, inflammation, lifespan, micronuclei, mitochondrial dysfunction, mitochondrial-derived peptides, mitochondrial-nuclear communication, mitophagy, MOTS-c, mtDNA, neurodegeneration, non-homologous end joining, NUMT, NUMTogenesis, oncogenesis, oxidative stress, pseudogenes, rapamycin, reactive oxygen species, resilience, retrograde signaling, somatic mutations, telomere attrition, transposable elements, whole-genome sequencing