The End of Immune Aging: This Simple Cell Transplant Rejuvenates Your System | Dr Amit Sharma

Dr. Amit Sharma reveals how gamma delta T cells outperform NK cells at clearing senescent cells and why they could reach the clinic faster than you'd expect. Some links are affiliate links so we will earn a commission when they are used to purchase products. If you would like to support our channel please consider joining our Patreon https://patreon.com/ModernHealthspan ~~~~~~~~~~~~~~ *Qualia* (15% off: MODERN) Creatine+ https://tinyurl.com/mr3z35jd Senolytic https://bit.ly/4jlaibe *Renue By Science* (10% off: MHS) https://tinyurl.com/bdew4bfs NMN Powder • Lipo NR *BiOptimizers* (15% off: MHBIO) https://bit.ly/47VAa8f - Magnesium Breakthrough, Gluten Guardian *Seeking Health* (10% off: Richard10) https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO *Stemregen* (15% off: MODERN) *US only* https://tinyurl.com/45z968yr *MitoQ* https://tinyurl.com/5n93fm3f MitoQ Pure https://tinyurl.com/3hxy9s7x *Wellness Extract* (10% off: MODERNWE) http://wellnessextract.com/RICHARDWE Geranylgeraniol • Vit E *n1o1* (10% off: Modern) https://tidd.ly/3IczGRW - Nitric Oxide Lozenges *AX3 Life* (20% off: MODERN20) https://tinyurl.com/2t3w26nw - Astaxanthin *Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder *Oxford Healthspan* (15% off: MHS) https://tinyurl.com/hrxfnzpn - Spermidine *ProHealth* (15% off: MODERN) https://prohealth.pxf.io/aObQRR NMNH 500mg These are affiliate links - using them supports the channel at no extra cost to you. ~~~~~~~~~~~~~~ Dr. Amit Sharma is Group Leader in Senescence Immunology at the Lifespan Research Institute, where his lab recently made a surprising discovery about a little-known immune cell that may be even more effective than natural killer cells at eliminating senescent cells. In this third segment, Dr. Sharma introduces gamma delta T cells — what they are, how they recognise senescent cells through a completely different mechanism to NK cells, and what his lab found when they tested them against senescent cells in the lab. The results were striking: gamma delta T cells cleared senescent cells faster and more selectively than any other immune cell they tested. He also shares early mouse data showing that transplanting healthy gamma delta T cells reduced both senescent cell burden and lung fibrosis — with potentially broad implications for fibrotic diseases. And he explains a particularly exciting finding: that expanding gamma delta T cells from older donors in the lab appears to rejuvenate them, which could make autologous therapy a real possibility. 🔬 Topics covered: 🔵 What gamma delta T cells are and how they differ from regular T cells 🔵 How they recognise senescent cells via metabolic stress, a different mechanism to NK cells 🔵 Why this dual recognition makes them harder for senescent cells to evade 🔵 Lab results showing gamma delta T cells outperform NK cells at clearing senescence 🔵 Mouse model data: transplanting gamma delta T cells reduces lung fibrosis 🔵 Can older people's gamma delta T cells be rejuvenated through expansion? 🔵 Off-the-shelf vs autologous therapy feasibility and cost 🔵 Why the path to the clinic may be shorter than for other cell therapies 🔵 NK cells vs gamma delta T cells; which will be used and when? ▶️ This is Part 3 of my full interview with Dr. Sharma. Links to other segments below as they are released. 📚 Chapters 0:00 What are gamma delta T cells? 1:44 How gamma delta T cells find and kill senescent cells 3:42 Mouse model results reducing lung fibrosis 4:00 Can we expand and rejuvenate gamma delta T cells? 7:23 Path to the clinic faster than you think 🌐Links in this video Lifespan Research Institute: https://lifespanresearchinstitute.io Dr Sharma's lab page https://lifespan.io/our-research/sharma-lab/ #Senolytics #Longevity #Senescence