How This Cell Clears the Roots of Aging | Dr Amit Sharma

Dr. Amit Sharma explains how NK cells can be engineered or transplanted to clear senescent cells and how this compares to senolytics like quercetin. Some links are affiliate links so we will earn a commission when they are used to purchase products. If you would like to support our channel please consider joining our Patreon https://patreon.com/ModernHealthspan ~~~~~~~~~~~~~~ *Qualia* (15% off: MODERN) Creatine+ https://tinyurl.com/mr3z35jd Senolytic https://bit.ly/4jlaibe *Renue By Science* (10% off: MHS) https://tinyurl.com/bdew4bfs NMN Powder • Lipo NR *BiOptimizers* (15% off: MHBIO) https://bit.ly/47VAa8f - Magnesium Breakthrough, Gluten Guardian *Seeking Health* (10% off: Richard10) https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO *Stemregen* (15% off: MODERN) *US only* https://tinyurl.com/45z968yr *MitoQ* https://tinyurl.com/5n93fm3f MitoQ Pure https://tinyurl.com/3hxy9s7x *Wellness Extract* (10% off: MODERNWE) http://wellnessextract.com/RICHARDWE Geranylgeraniol • Vit E *n1o1* (10% off: Modern) https://tidd.ly/3IczGRW - Nitric Oxide Lozenges *AX3 Life* (20% off: MODERN20) https://tinyurl.com/2t3w26nw - Astaxanthin *Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder *Oxford Healthspan* (15% off: MHS) https://tinyurl.com/hrxfnzpn - Spermidine *ProHealth* (15% off: MODERN) https://prohealth.pxf.io/aObQRR NMNH 500mg These are affiliate links - using them supports the channel at no extra cost to you. ~~~~~~~~~~~~~~ Dr. Amit Sharma is Group Leader in Senescence Immunology at the Lifespan Research Institute, where his lab is developing immune-based approaches to eliminate senescent cells and treat age-related disease. In this second segment, Dr. Sharma walks through the cutting-edge therapies his lab is working on; from transplanting healthy NK cells into older individuals, to engineering CAR-NK cells that can precisely target senescent cells. He also compares these immune-based approaches to existing senolytics like dasatinib and quercetin, explaining where each has advantages and limitations. He also reveals early work on a new small molecule approach targeting a unique vulnerability of senescent cells, their unusual relationship with iron and ferroptosis, and explains how the Lifespan Research Institute moves research from the lab toward the clinic. 🔬 Topics covered: - Adoptive transfer of NK cells: transplanting healthy immune cells to clear senescence - CAR-NK cells: engineering immune cells to precisely target senescent cells - Antibody-based approaches to enhance NK cell killing - Off-the-shelf NK cell therapies: how close are we? - How immune approaches compare to senolytics like dasatinib and quercetin - The senescence heterogeneity problem and why immune cells may solve it - New small molecule approaches targeting ferroptosis in senescent cells - How Lifespan Research Institute translates research toward the clinic ▶️ This is Part 2 of my full interview with Dr. Sharma. Links to other segments below as they are released. 📚 Chapters 0:00 Engineering NK cells to clear senescent cells 2:25 Off-the-shelf NK cell therapy, how close are we? 3:17 Immune approaches vs. senolytics 7:11 The senescence measurement problem 9:14 New small molecules and the path to clinic 🌐Links in this video Lifespan Research Institute: https://lifespanresearchinstitute.io Dr Sharma's lab page https://lifespan.io/our-research/sharma-lab/ #Senolytics #Longevity #Senescence